Photo-enhanced antibacterial activity of ZnO/graphene quantum dot nanocomposites
Photo-enhanced antibacterial activity of ZnO/graphene quantum dot nanocomposites
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DOI：
10.1039/c7nr07367d
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发表时间：
2018-01-07
期刊：
影响因子：
6.7
通讯作者：
Chen, Shaowei
中科院分区：
文献类型：
--
作者：
Liu, Junli;Rojas-Andrade, Mauricio D.;Chen, Shaowei
鉴于新出现的抗生素耐药性，合成新的高活性抗菌剂变得越来越重要。采用水热法制备了ZnO/石墨烯量子点（GQD）纳米复合材料，并通过透射电子显微镜、X射线光电子能谱、紫外-可见光谱和光致发光光谱等手段对其进行了表征。ZnO/GQD纳米复合材料的抗菌活性进行了评价与大肠杆菌的背景下的最低抑菌浓度和减少的细菌菌落数在一个标准的平板计数方法，与那些分别与ZnO和GQD。结果发现，在紫外光照射下的活性显着增强相比，在环境光。这是由于增强的产生活性氧在紫外光照射下，与膜损伤的微小贡献，表现在电子顺磁共振和荧光显微镜测量。结果突出了基于半导体纳米颗粒和石墨烯衍生物的功能纳米复合材料在开发有效杀菌剂中的重要性。
Synthesis of new, highly active antibacterial agents has become increasingly important in light of emerging antibiotic resistance. In the present study, ZnO/graphene quantum dot (GQD) nanocomposites were produced by a facile hydrothermal method and characterized by an array of microscopic and spectroscopic measurements, including transmission electron microscopy, X-ray photoelectron spectroscopy, UV-vis and photoluminescence spectroscopy. Antibacterial activity of the ZnO/GQD nanocomposites was evaluated with Escherichia coli within the context of minimum inhibitory concentration and the reduction of the number of bacterial colonies in a standard plate count method, in comparison to those with ZnO and GQD separately. It was found that the activity was markedly enhanced under UV photoirradiation as compared to that in ambient light. This was ascribed to the enhanced generation of reactive oxygen species under UV photoirradiation, with minor contributions from membrane damage, as manifested in electron paramagnetic resonance and fluorescence microscopic measurements. The results highlight the significance of functional nanocomposites based on semiconductor nanoparticles and graphene derivatives in the development of effective bactericidal agents.