Cutaneous T-cell Lymphoma and Pruritus: The Expression of IL-31 and its Receptors in the Skin
Cutaneous T-cell Lymphoma and Pruritus: The Expression of IL-31 and its Receptors in the Skin
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DOI：
10.2340/00015555-2417
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发表时间：
2016-11-01
影响因子：
3.6
通讯作者：
Yosipovitch, Gil
中科院分区：
文献类型：
--
作者：
Nattkemper, Leigh A.;Martinez-Escala, Maria-Estela;Yosipovitch, Gil
大约88%的皮肤T细胞淋巴瘤（CTCL）患者受到瘙痒的影响，目前的抗瘙痒治疗效果不佳。白细胞介素（IL）-31（一种Th 2细胞因子）已被发现在CTCL患者的血清中增加并且与瘙痒严重程度相关。本研究研究了IL-31及其受体（IL-31受体-α [IL-31 RA]和OSMR β）在轻度与中度/重度瘙痒CTCL患者皮肤中的作用。使用免疫组织化学测量皮肤中IL-31、IL-31 RA和OSMR β的表达水平，并将其与瘙痒严重程度和疾病阶段相关联。在中度/重度瘙痒的CTCL患者中，表皮和真皮浸润中的IL-31显著升高，而IL-31 RA和OSMR β仅在表皮中显著升高。此外，表皮IL-31水平与瘙痒严重程度相关。这些结果表明，IL-31可能通过表皮肿瘤性T细胞和角质形成细胞对感觉神经施加间接作用以传递瘙痒而在CTCL瘙痒中发挥作用。
Approximately 88% of cutaneous T-cell lymphoma (CTCL) patients are affected by pruritus that responds poorly to current antipruritic therapies. Interleukin (IL)-31, a Th2 cytokine, has been found to be increased in the serum of CTCL patients and to correlate with itch severity. This study investigated the role of IL-31 and its receptors (IL-31 receptor-alpha [IL-31RA] and OSMR beta) in the skin of CTCL patients with mild versus moderate/severe pruritus. Expression levels of IL31, IL-31RA, and OSMR beta in the skin were measured using immunohistochemistry and correlated to pruritus severity and disease stage. In CTCL patients with moderate/severe pruritus, IL-31 was significantly elevated in the epidermis and dermal infiltrate, while IL-31RA and OSMR beta were significantly elevated only in the epidermis. Furthermore, epidermal IL-31 levels correlated to itch severity. These results show that IL-31 may play a role in CTCL pruritus by exerting indirect effects on sensory nerves through epidermal neoplastic T cells and keratinocytes to transmit itch.