EFFECT OF ECDYSTERONE ON THE CYCLIC AMP PROTEIN KINASE SYSTEM IN MOUSE-LIVER
EFFECT OF ECDYSTERONE ON THE CYCLIC AMP PROTEIN KINASE SYSTEM IN MOUSE-LIVER
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DOI：
10.1016/0006-291x(79)90940-9
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发表时间：
1979-01-01
影响因子：
3.1
通讯作者：
MARTINEZ, AM
中科院分区：
文献类型：
--
作者：
CATALAN, RE;ARAGONES, MD;MARTINEZ, AM
蜕皮甾酮在体内给药后40分钟，小鼠肝脏中环[c]AMP水平和cAMP结合蛋白活性降低。这些变化伴随着cAMP依赖性蛋白激酶的减少。对磷蛋白磷酸酶的影响与对蛋白激酶的影响相反。cAMP-蛋白激酶系统可能参与蜕皮甾酮的异位作用。
In vivo administration of ecdysterone produced a decrease in cyclic[c]AMP levels and cAMP-binding protein activity in mouse liver 40 min after injection. These changes were accompanied by a concomitant decrease in cAMP-dependent protein kinase. The effect on phosphoprotein phosphatase was the opposite pattern of that on protein kinase. The cAMP-protein kinase system may be involved in the heterophylic action of ecdysterone.