Hematopoietic Stem and Progenitor Cells (HSPCs)
Hematopoietic Stem and Progenitor Cells (HSPCs)
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DOI：
10.1007/978-3-030-31206-0_3
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发表时间：
2019-01-01
期刊：
影响因子：
--
通讯作者：
Ratajczak, Mariusz Z.
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文献类型：
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作者：
Bujko, Kamila;Kucia, Magda;Ratajczak, Mariusz Z.
从骨髓中分离的造血干/祖细胞（HSPCs）已经成功地用于血液移植50年。目前，这些细胞更频繁地从动员的外周血或脐带血中分离。在这一章中，我们概述了几个主题，这些细胞，包括他们的表型，分离方法，并在体外和体内试验，以评估其增殖潜力。HSPC的成功临床应用被广泛认为有助于建立干细胞疗法和再生医学发展的基本原理。
Hematopoietic stem/progenitor cells (HSPCs) isolated from bone marrow have been successfully employed for 50 years in hematological transplantations. Currently, these cells are more frequently isolated from mobilized peripheral blood or umbilical cord blood. In this chapter, we overview several topics related to these cells including their phenotype, methods for isolation, and in vitro and in vivo assays to evaluate their proliferative potential. The successful clinical application of HSPCs is widely understood to have helped establish the rationale for the development of stem cell therapies and regenerative medicine.