Microstimulation of macaque V1 disrupts target selection: effects of stimulation polarity
Microstimulation of macaque V1 disrupts target selection: effects of stimulation polarity
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DOI：
10.1007/s00221-002-1312-5
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发表时间：
2003-01-01
影响因子：
2
通讯作者：
Slocum, WM
中科院分区：
文献类型：
--
作者：
Tehovnik, EJ;Slocum, WM
对恒河猴 VI 中间层的微刺激会通过眼球扫视运动扰乱目标选择。为了研究目标选择，在受刺激神经元的感受野位置呈现一个视觉目标，并在该位置之外呈现第二个目标。当 VI 中间层受到刺激时，随着两个目标出现而传递的微刺激降低了猴子选择位于感受野位置的目标的概率。与使用阴极优先脉冲对相比，当使用阳极优先脉冲对时，这种干扰效应更加明显。阳极脉冲的卓越有效性表明干扰效应是由于位于中间 VI 内的轴突末端的激活所致。
Microstimulation of the intermediate layers of VI in rhesus monkeys disrupts target selection with saccadic eye movements. To study target selection, one visual target was presented in the receptive-field location of the stimulated neurons and a second target was presented outside this location. Microstimulation delivered with the appearance of the two targets decreased the probability that the monkey would select the target placed in the receptive-field location when intermediate layers of VI were stimulated. This interference effect was more pronounced when anodal-first pulse pairs were used as compared to when cathodal-first pulse pairs were used. The superior effectiveness of anodal pulses suggests that the interference effect is due to activation of axonal terminals residing within intermediate VI.