Oxidative stress is associated with migraine and migraine-related metabolic risk in females
Oxidative stress is associated with migraine and migraine-related metabolic risk in females
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DOI：
10.1111/j.1468-1331.2011.03414.x
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发表时间：
2011-10-01
影响因子：
5.1
通讯作者：
Gruber, H. -J.
中科院分区：
文献类型：
--
作者：
Bernecker, C.;Ragginer, C.;Gruber, H. -J.
背景和目的：氧化应激被认为与偏头痛的病理生理有关。然而，数据在一定程度上存在争议，迄今为止可能的潜在机制仍然难以捉摸。本研究的目的是探讨女性偏头痛患者的氧化应激状态及其对偏头痛相关代谢改变的影响。方法：在女性偏头痛患者和对照组的发作间期测定氧化应激标志物丙二醛（MDA）、4-羟基-2-壬烯醛（HNE）、羰基化蛋白、相关一氧化氮应激参数、炎症、脂质和葡萄糖代谢。我们发现女性偏头痛患者的HNE水平与对照组相比显著升高。HNE的Logistic回归分析显示偏头痛的优势比为4.55。HNE表现出显着的相关性与一氧化氮途径，胰岛素和脂质代谢。结论：我们在这里表明，增加氧化应激与偏头痛，并有助于偏头痛相关的代谢风险，如亚硝化应激，致动脉粥样硬化的血脂和高胰岛素血症。我们的数据表明，氧化应激可能是偏头痛病理生理学的关键事件，也是一个合适的治疗靶点。
Background and purpose: Oxidative stress is discussed to be implicated in the pathophysiology of migraine. However, data are in part controversial and the possible underlying mechanisms remain elusive to date. The aim of this study was to investigate the oxidative stress status of female patients with migraine and its implications on migraine-related metabolic alterations.Methods: Oxidative stress markers malondialdehyde (MDA), 4-hydroxy-2-nonenal (HNE), carbonylated proteins, parameters of associated nitric oxide stress, inflammation, lipid-and glucose-metabolism were determined in the interictal phase in female patients with migraine and controls.Results: We found significantly increased HNE levels in female migraineurs compared with controls. Logistic regression analyses of HNE revealed an odds ratio for migraine of 4.55. HNE showed significant correlations with the nitric oxide pathway, the insulin-and the lipid-metabolism.Conclusions: We show here that increased oxidative stress is associated with migraine and contributes to migraine-related metabolic risk like nitrosative stress, an atherogenic lipid profile and hyperinsulinemia. Our data suggest that oxidative stress may represent a key event in the pathophysiology of migraine and a suitable therapeutic target.