Functional Connectivity is Reduced in Early-stage Primary Progressive Aphasia When Atrophy is not Prominent.
Functional Connectivity is Reduced in Early-stage Primary Progressive Aphasia When Atrophy is not Prominent.
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DOI：
10.1097/wad.0000000000000193
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发表时间：
2017-04
影响因子：
2.1
通讯作者：
Hurley RS
中科院分区：
文献类型：
--
作者：
Bonakdarpour B;Rogalski EJ;Wang A;Sridhar J;Mesulam MM;Hurley RS
原发性进行性失语（PPA）是一种由神经退行性病变引起的语言功能减退的临床综合征。虽然PPA中的语言障碍通常通过萎缩的形态学评估进行定位，但功能变化可能伴随或甚至先于可检测的结构改变，在这种情况下，静息状态功能连接（RSFC）可以提供另一种方法。本研究的目的是确定在PPA的早期阶段，当萎缩不明显时，语言网络RSFC是否减少。我们确定了10个人与早期无语法变体PPA（PPA-G）没有显着的皮层变薄相比，非失语症的控制。在PPA-G和健康对照参与者之间比较语言网络的两个节点和默认模式网络的两个节点之间的RSFC。语言网络连接与对照组相比，在轻度语法缺失患者中，但在更明显的语法缺失患者中显著降低。在默认模式网络连接中未观察到组间差异，证明了结果的特异性。在PPA的早期阶段，当皮质萎缩不突出时，RSFC提供了一种探索语言障碍的神经解剖学基础的替代方法。RSFC在神经退行性疾病的早期干预研究中可能特别有用，可以识别干预的解剖靶点，也可以作为治疗效果的结果指标。
Primary progressive aphasia (PPA) is a clinical syndrome of language decline caused by neurodegenerative pathology. Although language impairments in PPA are typically localized via the morphometric assessment of atrophy, functional changes may accompany or even precede detectable structural alterations, in which case resting state functional connectivity (RSFC) could provide an alternative approach. The goal of this study was to determine whether language network RSFC is reduced in early stage PPA when atrophy is not prominent. We identified 10 individuals with early stage agrammatic-variant PPA (PPA-G) with no prominent cortical thinning compared to non-aphasic controls. RSFC between two nodes of the language network and two nodes of the default mode network were compared between PPA-G and healthy control participants. Language network connectivity was comparable to controls among patients with milder agrammatism, but was significantly reduced in patients with more pronounced agrammatism. No group differences were observed in default mode network connectivity, demonstrating specificity of findings. In early stages of PPA when cortical atrophy is not prominent, RSFC provides an alternative method for probing the neuroanatomic substrates of language impairment. RSFC may be of particular utility in studies on early interventions for neurodegenerative disease, either to identify anatomic targets for intervention or as an outcome measure of therapeutic efficacy.