The neuroanatomy of amnesia: amygdala-hippocampus versus temporal stem.
The neuroanatomy of amnesia: amygdala-hippocampus versus temporal stem.
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遗忘症的神经解剖学：杏仁核-海马与颞干。
DOI：
10.1126/science.6890713
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Mishkin,M
中科院分区：
文献类型：
--
作者：
Zola-Morgan,S;Squire,LR;Mishkin,M
使用一项对人类健忘症敏感的任务，我们评估了目前的两种假设，即哪些大脑区域必须受损才能产生这种疾病。双侧横断颞叶白质的猴子没有受到损害，但杏仁核-海马区联合损伤的猴子表现出严重的记忆缺陷。结果表明，海马体、杏仁核或两者都参与了猴子的记忆，但与颞叶干无关，这表明人类和非人类灵长类动物的研究结果之间的和解可能近在眼前。
Using a task known to be sensitive to human amnesia, we have evaluated two current hypotheses about which brain regions must be damaged to produce the disorder. Monkeys with bilateral transections of the white matter of the temporal stem were unimpaired, but monkeys with conjoint amygdala-hippocampal lesions exhibited a severe memory deficit. The results indicate that the hippocampus, amygdala, or both, but not the temporal stem, are involved in memory in the monkey and suggest that a rapprochement between the findings for the human and the nonhuman primate may be close at hand.