Assessing potential health risks from microcystin toxins in blue-green algae dietary supplements
Assessing potential health risks from microcystin toxins in blue-green algae dietary supplements
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DOI：
10.2307/3454384
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发表时间：
2000-05-01
影响因子：
10.4
通讯作者：
Chu, FS
中科院分区：
文献类型：
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作者：
Gilroy, DJ;Kauffman, KW;Chu, FS
作为一个公共卫生问题，蓝绿藻（EGA）毒素在用于饮用水源和娱乐的地表沃茨中的存在正受到世界各地越来越多的关注。然而，在含有EGA的受污染健康食品中暴露于这些毒素的潜在风险在很大程度上被忽视了。EGA产品通常在美国，加拿大和欧洲消费，因为它们具有公认的有益效果，包括增加能量和改善情绪。这些产品中的许多含有水华束丝藻，这是一种从俄勒冈州南部的上克拉马斯湖（UKL）收获的EGA，在那里经常发生有毒EGA铜绿微囊藻的生长。铜绿微囊藻产生一种叫做微囊藻毒素的化合物，它是一种有效的肝毒素，可能是肿瘤的促进剂。因为M. aeruginosa与A.由于藻类是絮状水生物，在收获过程中可能无意中被收集，导致EGA产品受到微囊藻毒素污染。1996年秋天，俄勒冈州卫生部获悉，UKL正在经历一场广泛的M。绿脓杆菌水华，并发布了一项建议，建议不要与水接触。这一建议引起了EGA产品消费者的呼吁，他们对这些产品可能受到微囊藻毒素污染表示担忧。作为回应，俄勒冈州卫生部和俄勒冈州农业部规定含EGA产品中微囊藻毒素的监管限值为1 μ g/g，并对EGA产品进行了微囊藻毒素检测。在87个检测样本中，有85个样本检测到微囊藻毒素，其中63个样本（72%）的浓度> 1微克/克。HPLC和ELISA初步确定微囊藻毒素-1R，最具毒性的微囊藻毒素变体，作为主要的同源物。
The presence of blue-green algae (EGA) toxins in surface waters used for drinking water sources and recreation is receiving increasing attention around the world as a public health concern. However, potential risks from exposure to these toxins in contaminated health food products that contain EGA have been largely ignored. EGA products are commonly consumed in the United States, Canada, and Europe for their putative beneficial effects, including increased energy and elevated mood. Many of these products contain Aphanizomenon flos-aquae, a EGA that is harvested from Upper Klamath Lake (UKL) in southern Oregon, where the growth of a toxic EGA, Microcystis aeruginosa, is a regular occurrence. M, aeruginosa produces compounds called microcystins, which are potent hepatotoxins and probable tumor promoters. Because M. aeruginosa coexists with A. flos-aquae, it can be collected inadvertently during the harvesting process, resulting in microcystin contamination of EGA products. In fall 1996, the Oregon Health Division learned that UKL was experiencing an extensive M. aeruginosa bloom, and an advisory was issued recommending against water contact. The advisory prompted calls from consumers of EGA products, who expressed concern about possible contamination of these products with microcystins. In response, the Oregon Health Division and the Oregon Department of Agriculture established a regulatory limit of 1 mu g/g for microcystins in EGA-containing products and tested EGA products for the presence of microcystins. Microcystins were detected in 85 of 87 samples tested, with 63 samples (72%) containing concentrations > 1 mu g/g. HPLC and ELISA tentatively identified microcystin-1R, the most toxic microcystin variant, as the predominant congener.