Dose-response relationship between cigarette smoking and risk of ischemic stroke in young women.
Dose-response relationship between cigarette smoking and risk of ischemic stroke in young women.
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DOI：
10.1161/strokeaha.107.510073
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发表时间：
2008-09
期刊：
影响因子：
8.3
通讯作者：
Kittner SJ
中科院分区：
文献类型：
--
作者：
Bhat VM;Cole JW;Sorkin JD;Wozniak MA;Malarcher AM;Giles WH;Stern BJ;Kittner SJ
虽然吸烟是已知的缺血性卒中的危险因素，但在年轻的不同种族人群中，吸烟与卒中风险之间的剂量-反应关系的数据很少。我们使用来自年轻女性卒中预防研究的数据，这是一项基于人群的病例对照研究，研究了15至49岁女性缺血性卒中的危险因素，以研究吸烟与缺血性卒中之间的关系。包括吸烟史在内的历史数据通过标准化访谈获得。使用逻辑回归估计比值比（OR）。病例组（n=466）为大巴尔的摩-华盛顿地区的中风妇女，对照组（n=604）为通过随机数字拨号确定的无中风史的妇女。经多变量校正后，目前吸烟者与从不吸烟者的OR为2.6（P<0.0001）;既往吸烟者与从不吸烟者之间的卒中风险无差异。调整后的OR随着每天吸烟数量的增加而增加（OR=2.2，1至10支/天; 2.5，11至20支/天; 4.3，21至39支/天; 9.1，40支或更多支/天）。这些结果表明，吸烟与年轻女性缺血性中风风险之间存在强烈的剂量反应关系，并加强了年轻人积极戒烟的必要性。
Although cigarette smoking is known to be a risk factor for ischemic stroke, there are few data on the dose-response relationship between smoking and stroke risk in a young ethnically diverse population. We used data from the Stroke Prevention in Young Women Study, a population-based case-control study of risk factors for ischemic stroke in women aged 15 to 49 years to examine the relationship between cigarette smoking and ischemic stroke. Historical data, including smoking history, was obtained through standardized interviews. Odds ratios (OR) were estimated using logistic regression. Cases (n=466) were women with stroke in the greater Baltimore-Washington area, and controls (n=604) were women free of a stroke history identified by random digit dialing. After multivariable adjustment, the OR comparing current smokers to never smokers was 2.6 (P<0.0001); no difference in stroke risk was observed between former smokers and never smokers. Adjusted OR increased with increasing number of cigarettes smoked per day (OR=2.2 for 1 to 10 cigs/d; 2.5 for 11 to 20 cigs/d; 4.3 for 21 to 39 cigs/d; 9.1 for 40 or more cigs/d). These results suggest a strong dose-response relationship between cigarette smoking and ischemic stroke risk in young women and reinforce the need for aggressive smoking cessation efforts in young adults.