Passive Acoustic Mapping with the Angular Spectrum Method.
Passive Acoustic Mapping with the Angular Spectrum Method.
复制标题
用角谱法被动声映射。
DOI：
10.1109/tmi.2016.2643565
复制
发表时间：
2017-04
影响因子：
10.6
通讯作者：
Clement GT
中科院分区：
文献类型：
--
作者：
Arvanitis CD;Crake C;McDannold N;Clement GT
在目前的原理证明研究中，我们使用模拟和实验数据对微气泡振动的被动声映射的均匀角谱方法(AS-PAM)进行了评估。在模拟数据中，我们评估了AS-PAM形成单个和多个点源的3D地图的能力。然后，在二维范围内，我们比较了AS-PAM与交替频率和时间域被动声映射(FD-PAM和TD-PAM)的二维图。最后，我们使用临床MR引导的FUS系统，使用8个不同的实验数据来评估AS-PAM在活体中显示微泡活动的能力。实验结果表明，AS-PAM可用于进行三维被动声映射。与FD-PAM和TD-PAM相比，2D AS-PAM的速度分别快10倍和200倍，即使在噪声比信号高10倍的情况下，也具有相似的灵敏度、分辨率和定位精度。在体内，AS-PAM对与不同类型微泡振荡相关的频段发射的重建也被发现比TD-PAM更敏感。只有谐波成分的AS-PAM预测安全的血脑屏障破坏，而宽带发射的AS-PAM正确识别MR明显的组织损伤。三种方法在空化活动位置上的差异(3.2毫米)在其分辨率范围内。这些数据清楚地表明，AS-PAM是治疗PAM的一种敏感和快速的方法，从而为指导治疗性超声操作提供了一种具有临床意义的方法。
In the present proof of principle study, we evaluated the homogenous angular spectrum method for passive acoustic mapping (AS-PAM) of microbubble oscillations using simulated and experimental data. In the simulated data we assessed the ability of AS-PAM to form 3D maps of a single and multiple point sources. Then, in the two dimensional limit, we compared the 2D maps from AS-PAM with alternative frequency and time domain passive acoustic mapping (FD- and TD-PAM) approaches. Finally, we assessed the ability of AS-PAM to visualize microbubble activity in vivo with data obtained during 8 different experiments of FUS-induced blood-brain barrier disruption in 3 nonhuman primates, using a clinical MR-guided FUS system. Our in silico results demonstrate AS-PAM can be used to perform 3D passive acoustic mapping. 2D AS-PAM as compared to FD- PAM and TD-PAM is 10 and 200 times faster respectively and has similar sensitivity, resolution, and localization accuracy, even when the noise was 10-fold higher than the signal. In-vivo, the AS-PAM reconstructions of emissions at frequency bands pertinent to the different types of microbubble oscillations were also found to be more sensitive than TD-PAM. AS-PAM of harmonic-only components predicted safe blood-brain barrier disruption, whereas AS-PAM of broadband emissions correctly identified MR-evident tissue damage. The disparity (3.2mm) in the location of the cavitation activity between the three methods was within their resolution limits. These data clearly demonstrate that AS-PAM is a sensitive and fast approach for PAM, thus providing a clinically relevant method to guide therapeutic ultrasound procedures.