Synchronous and metachronous colorectal carcinoma.
Synchronous and metachronous colorectal carcinoma.
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DOI：
10.1007/s10151-004-0124-y
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发表时间：
2004-11-01
影响因子：
3.3
通讯作者：
Harlaftis, N
中科院分区：
文献类型：
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作者：
Papadopoulos, V;Michalopoulos, A;Harlaftis, N
背景：同步和异时性结直肠癌的发病率为2-10%。本研究的目的是评估这些患者的临床特征、诊断检查的准确性和生存率。方法：1970 ~ 1999年，我科收治结直肠癌患者1160例。在随访检查中，50例（4.3%）患者发现多发性原发性结肠癌。52%为同步肿瘤，48%为异时肿瘤。结果：患者5年总生存率为45.87%。多发原发癌患者的死亡率为10%，而单发癌患者的死亡率为4.1%。多发原发肿瘤患者的5年总生存率为46.67%。结论：必须对结直肠癌患者进行充分的内镜检查。近年来，由于更好的手术技术，更复杂的检查方法的引入以及对危险患者的细致随访，生存率有所提高。
BACKGROUND: Synchronous and metachronous colorectal carcinoma have an incidence of 2-10%. The purpose of the study was to evaluate the clinical characteristics, the accuracy of diagnostic examinations and the survival of these patients.METHODS: From 1970 to 1999, 1160 patients with colorectal cancer were admitted to our Department. During follow-up examination 50 patients (4.3%) were found to present with multiple primary colon cancers. Fifty-two per cent were synchronous and 48% metachronous tumours.RESULTS: The overall 5-year survival of the patients was 45.87%. Mortality was 10% for multiple primaries, while in patients with single cancer was 4.1%. The overall 5-year survival of the patients with multiple primaries tumours was 46.67%.CONCLUSIONS: Patients with colorectal cancer must be fully studied endoscopically. There has been an improvement in survival in recent years due to better surgical techniques, the introduction of more sophisticated examination methods and the meticulous follow-up of patients at risk.