mtDNA analysis in ancient Nubians supports the existence of gene flow between sub-Sahara and North Africa in the Nile valley
mtDNA analysis in ancient Nubians supports the existence of gene flow between sub-Sahara and North Africa in the Nile valley
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DOI：
10.1080/03014469700004952
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发表时间：
1997-05-01
影响因子：
1.7
通讯作者：
Fox, CL
中科院分区：
文献类型：
--
作者：
Fox, CL
Hpal（np3，592）线粒体DNA标记是一种选择性中性突变，在撒哈拉以南非洲非常常见，在北非和欧洲人群中几乎不存在。通过PCR扩增和后酶消化，在来自古努比亚的Meroitic样本中筛选了该基因，以评估撒哈拉以南地区对该人群的遗传影响。从分析的29个个体中，只有15个产生阳性扩增，其中4个（26.7%）显示撒哈拉以南非洲标记。Hpa I（np 3，592）标记在撒哈拉以南非洲人群中的平均频率为68.7。因此，来自该地区的基因在Melotic Nubian人群中的频率可以估计为约39%（置信区间为22%至55%）。所获得的频率符合Hpa I（np 3，592）沿着非洲大陆的南北递减梯度。结果表明，在努比亚人口的历史上观察到的形态变化更有可能是由于存在的南北基因流通过尼罗河流域比原位进化。
The Hpal (np3,592) mitochondrial DNA marker is a selectively neutral mutation that is very common in sub-Saharan Africa and is almost absent in North African and European populations. It has been screened in a Meroitic sample from ancient Nubia through PCR amplification and posterior enzyme digestion, to evaluate the sub-Saharan genetic influences in this population. From 29 individuals analysed, only 15 yield positive amplifications, four of them (26.7%) displaying the sub-Saharan African marker. Hpa I (np3,592) marker is present in the sub-Saharan populations at a frequency of 68.7 on average. Thus, the frequency of genes From this area in the Merotic Nubian population can be estimated at around 39% (with a confidence interval From 22% to 55%). The frequency obtained fits in a south-north decreasing gradient of Hpa I (np3,592) along the African continent. Results suggest that morphological changes observed historically in the Nubian populations are more likely to be due to the existence of south-north gene flow through the Nile Valley than to in-situ evolution.