Emerging mechanisms of neutrophil recruitment across endothelium.

Emerging mechanisms of neutrophil recruitment across endothelium.
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DOI:
10.1016/j.it.2011.06.009
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发表时间:
2011-10
影响因子:
16.8
通讯作者:
Luscinskas FW
Luscinskas FW
中科院分区:
医学1区
文献类型:
--
作者:
Williams MR;Azcutia V;Newton G;Alcaide P;Luscinskas FW

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Neutrophils are the all-terrain vehicle of the innate immune system because of their ability to gain entry into tissues and organs, and thus, play an essential role in host defense. Exactly how this marvel of nature works is still incompletely understood. In the last two to three years, new players and processes have been identified in the endothelial - leukocyte adhesion cascade. Novel signaling pathways have been discovered in both the endothelium and the neutrophil that regulate various steps in the recruitment process. This review focuses on these emerging pathways and the mechanisms that regulate neutrophil recruitment across endothelium.
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