Aviram-Ratner rectifying mechanism for DNA base-pair sequencing through graphene nanogaps.
Aviram-Ratner rectifying mechanism for DNA base-pair sequencing through graphene nanogaps.
复制标题
通过石墨烯纳米间隙进行 DNA 碱基对测序的 Aviram-Ratner 校正机制。
DOI：
10.1088/0957-4484/23/13/135202
复制
发表时间：
2012
期刊：
影响因子：
3.5
通讯作者：
Kioussis,Nicholas
中科院分区：
文献类型：
--
作者：
Agapito,LuisA;Gayles,Jacob;Wolowiec,Christian;Kioussis,Nicholas
我们证明，生物分子，如沃森-克里克DNA碱基对可以作为生物Aviram-Ratner整流器，因为空间分离和弱氢键之间的核碱基。我们已经进行了一个并行计算的从头算非平衡绿色函数（NEGF）的理论，以确定石墨烯基对石墨烯结的电响应。结果显示吸附在石墨烯纳米间隙上的胞嘧啶-鸟嘌呤碱基对的不对称（整流）电流-电压响应。与此形成鲜明对比的是，我们发现胸腺嘧啶-腺嘌呤的情况下，一个对称的反应。我们建议将电流-电压响应的不对称性作为传感标准应用于通过石墨烯纳米间隙进行快速DNA测序的技术挑战。
We demonstrate that biological molecules such as Watson–Crick DNA base pairs can behave as biological Aviram–Ratner electrical rectifiers because of the spatial separation and weak hydrogen bonding between the nucleobases. We have performed a parallel computational implementation of the ab initio non-equilibrium Green's function (NEGF) theory to determine the electrical response of graphene—base-pair—graphene junctions. The results show an asymmetric (rectifying) current–voltage response for the cytosine–guanine base pair adsorbed on a graphene nanogap. In sharp contrast we find a symmetric response for the thymine–adenine case. We propose applying the asymmetry of the current–voltage response as a sensing criterion to the technological challenge of rapid DNA sequencing via graphene nanogaps.