Lingering Questions about Enhancer RNA and Enhancer Transcription-Coupled Genomic Instability.
Lingering Questions about Enhancer RNA and Enhancer Transcription-Coupled Genomic Instability.
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DOI：
10.1016/j.tig.2016.12.002
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发表时间：
2017-02
期刊：
影响因子：
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通讯作者：
Basu U
中科院分区：
文献类型：
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作者：
Rothschild G;Basu U
在拓扑相关调控域（TADs）内发现的基因间和基因内增强子表达非编码rna，称为增强子rna （eRNAs）。最近的研究表明，这些erna通过控制启动子和增强子的相互作用以及高阶染色质结构的拓扑结构在基因调控网络中发挥作用。增强子和启动子相关非编码RNA （ncRNAs）的错误调控可以稳定有害的次级DNA结构，非编码RNA相关DNA/RNA杂交形成，并促进转录复合物与复制体的碰撞。它揭示了许多染色体畸变，其中一些与恶性肿瘤有关，存在于增强子和/或启动子序列内。在这里，我们扩展当前的概念来讨论增强子rna和增强子转录，以及增强子转录如何影响基因组的组织和完整性。
Intergenic and intragenic enhancers found inside topologically associated regulatory domains (TADs) express noncoding RNAs, known as enhancer RNAs (eRNAs). Recent studies have indicated these eRNAs play a role in gene regulatory networks by controlling promoter and enhancer interactions and topology of higher-order chromatin structure. Misregulation of enhancer and promoter associated noncoding RNAs (ncRNAs) could stabilize deleterious secondary DNA structures, noncoding RNA associated DNA/RNA hybrid formation, and promote collisions of transcription complexes with replisomes. It is revealing that many chromosomal aberrations, some associated with malignancies, are present inside enhancer and/or promoter sequences. Here, we expand on current concepts to discuss enhancer RNAs and enhancer transcription, and how enhancer transcription influences genomic organization and integrity.