Nodal Stage: Is It a Prognostic Factor for Submandibular Gland Cancer?
Nodal Stage: Is It a Prognostic Factor for Submandibular Gland Cancer?
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淋巴结分期：它是颌下腺癌的预后因素吗？
DOI：
10.1016/j.joms.2017.11.012
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发表时间：
2018-08-01
影响因子：
1.9
通讯作者：
Han, Zhengxue
中科院分区：
文献类型：
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作者：
Liu, Yanbin;Qin, Lizheng;Han, Zhengxue
目的：下颌下腺癌是一种比较少见的肿瘤。本研究的目的是估计5年的总生存率（OS）和无病生存（DFS），并确定与OS和DFS为下颌下腺cancer.Materials和方法的预后因素：作者实施了一项回顾性队列研究，并纳入样本的患者与下颌下腺癌。预测变量为年龄、性别、肿瘤分期、淋巴结分期、边缘状态和包膜外扩散。结果变量为5年OS和5年DFS。Kaplan-Meier方法被用来估计生存和考克斯风险模型被用来确定预后variables.Results：该样本是由52例下颌下腺癌（平均年龄47.4岁，51.9%的男性）。中位随访时间为81个月（范围：11 - 159个月）。5年OS和DFS率分别为76.9%和67.3%。固定肿块、颈淋巴结阳性和切缘阳性状态是OS和DFS的相关预测因素。结分期是影响下颌下腺癌预后的独立预测因子。结论：这些结果确定了几个与下颌下腺癌患者生存率相关的重要预后因素。这些预后变量包括临床症状、病理淋巴结状态和边缘状态。这些结果表明，提高对这种疾病的临床特征的警惕可能会为提高生存率提供动力。(C)2018由Elsevier Inc代表美国口腔颌面外科医师协会发布
Purpose: Submandibular gland cancer is relatively rare. The purpose of this study was to estimate 5-year overall survival (OS) and disease-free survival (DFS) and to identify prognostic factors associated with OS and DFS for submandibular cancer.Materials and Methods: The authors implemented a retrospective cohort study and enrolled a sample of patients with submandibular gland cancer. The predictor variables were age, gender, tumor stage, nodal stage, margin status, and extracapsular spread. The outcome variables were 5-year OS and 5-year DFS. Kaplan-Meier methods were used to estimate survival and Cox hazards models were used to identify prognostic variables.Results: The sample was composed of 52 patients with submandibular gland cancer (mean age, 47.4 yr; 51.9% men). The median follow-up was 81 months (range, 11 to 159 months). The 5-year OS and DFS rates were 76.9 and 67.3%, respectively. Fixed mass, positive neck node, and positive margin status were relevant predictors of OS and DFS. Nodal stage was the relevant independent predictor affecting the disease outcome of submandibular gland cancer.Conclusion: These results identified several important prognostic factors associated with survival rate in patients with submandibular gland cancer. These prognostic variables include symptoms at presentation, pathologic nodal status, and margin status. These outcomes suggest that heightening vigilance of clinical characteristics for this disease might provide the impetus for improving the survival rate. (C) 2018 Published by Elsevier Inc on behalf of the American Association of Oral and Maxillofacial Surgeons