Setting up presynaptic structures at specific positions.
Setting up presynaptic structures at specific positions.
复制标题
在特定位置建立突触前结构。
DOI：
10.1016/j.conb.2010.04.011
复制
发表时间：
2010
影响因子：
5.7
通讯作者：
Shen,Kang
中科院分区：
文献类型：
--
作者：
Ou,Chan-Yen;Shen,Kang
特定位点突触前结构的精确形成对于正确连接神经元回路至关重要。最近的研究结果逐渐揭示了来自不同来源的基本线索如何通知轴突定义突触前区域并选择其突触后目标。在这里，我们回顾了介导来自多个来源（包括靶细胞、局部导柱细胞和远端引导组织）的指示性或排斥性信号的关键分子调节因子。
Precise formation of presynaptic structures at specific loci is critical for correctly wiring neuronal circuits. Recent findings have gradually revealed how essential cues from different sources inform the axon to define the presynaptic domain and to choose its postsynaptic target. Here, we review key molecular regulators which mediate instructive or repellent signals from multiple sources including the target cells, local guidepost cells, and distal guiding tissues.