Disease-free survival after complete mesocolic excision compared with conventional colon cancer surgery: a retrospective, population-based study
Disease-free survival after complete mesocolic excision compared with conventional colon cancer surgery: a retrospective, population-based study
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DOI：
10.1016/s1470-2045(14)71168-4
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发表时间：
2015-02-01
期刊：
影响因子：
51.1
通讯作者：
Gogenur, Ismail
中科院分区：
文献类型：
--
作者：
Bertelsen, Claus Anders;Neuenschwander, Anders Ulrich;Gogenur, Ismail
背景：已提出将全肠系膜切除（CME）的原则应用于结肠癌，以改善肿瘤预后。我们的目的是研究与常规结肠切除术相比，CME的实施是否能提高无病生存。方法：在2008年6月1日至2011年12月31日期间，在丹麦首都地区接受国际癌症控制联盟（UICC） iii期结肠腺癌选择性切除术的所有患者的数据，用于这项基于人群的研究。CME组包括在经验证可以进行CME手术的中心接受CME手术的患者；对照组为在其他三家医院行常规结肠切除术的患者。数据收集自丹麦结直肠癌组（DCCG）数据库和医学图表。如果患者患有IV期疾病、异时性结直肠癌、直肠癌(
Background Application of the principles of total mesorectal excision to colon cancer by undertaking complete mesocolic excision (CME) has been proposed to improve oncological outcomes. We aimed to investigate whether implementation of CME improved disease-free survival compared with conventional colon resection.Methods Data for all patients who underwent elective resection for Union for International Cancer Control (UICC) stage IIII colon adenocarcinomas in the Capital Region of Denmark between June 1, 2008, and Dec 31, 2011, were retrieved for this population-based study. The CME group consisted of patients who underwent CME surgery in a centre validated to perform such surgery; the control group consisted of patients undergoing conventional colon resection in three other hospitals. Data were collected from the Danish Colorectal Cancer Group (DCCG) database and medical charts. Patients were excluded if they had stage IV disease, metachronous colorectal cancer, rectal cancer (