The effects of dynamic optical properties during interstitial laser photocoagulation
The effects of dynamic optical properties during interstitial laser photocoagulation
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DOI：
10.1088/0031-9155/45/5/317
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发表时间：
2000-05-01
影响因子：
3.5
通讯作者：
Sherar, MD
中科院分区：
文献类型：
--
作者：
Iizuka, MN;Vitkin, IA;Sherar, MD
建立了一个非线性数学模型，并进行了实验验证，研究了间隙激光光凝过程中光学性质变化的影响。利用Arrhenius损伤模型计算了动态光学特性的影响，得到了非线性光热响应。通过测量蛋白和聚丙烯酰胺幻影的温升，实验验证了这种反应。在峰值温度低于汽化阈值的条件下，对肝脏中的ILP进行了理论研究。温度预测在静态和动态情景之间变化很大，并在实验中得到了证实。这表明Arrhenius模型可以用来预测光场和热场的动态变化。在肝脏ILP期间，由于在凝固区域内光穿透的减少，温升的增加也被证明。由于凝固作用，ILP的动力学是复杂的和非线性的，这改变了治疗过程中的组织特性。这些复杂的效应可以用阿伦尼乌斯损伤公式来充分模拟。
A nonlinear mathematical model was developed and experimentally validated to investigate the effects of changes in optical properties during interstitial laser pholocoagulation (ILP). The effects of dynamic optical properties were calculated using the Arrhenius damage model, resulting in a nonlinear optothermal response. This response was experimentally validated by measuring the temperature rise in albumen and polyacrylamide phantoms. A theoretical study of ILP in liver was conducted constraining the peak temperatures below the vaporization threshold. The temperature predictions varied considerably between the static and dynamic scenarios, and were confirmed experimentally in phantoms. This suggests that the Arrhenius model can be used to predict dynamic changes in optical and thermal fields. An increase in temperature rise due to a decrease in light penetration within the coagulated region during ILP of the liver was also demonstrated. The kinetics of ILP are complex and nonlinear due to coagulation, which changes the tissue properties during treatment. These complex effects can be adequately modelled using an Arrhenius damage formulation.