Effects of gap geometry on conduction through discontinuous radiofrequency lesions
Effects of gap geometry on conduction through discontinuous radiofrequency lesions
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DOI：
10.1161/circulationaha.105.596593
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发表时间：
2006-04-11
期刊：
影响因子：
37.8
通讯作者：
Schubert, CM
中科院分区：
文献类型：
--
作者：
Pérez, FJ;Wood, MA;Schubert, CM
背景-线性射频(RF)病变内具有足够横截面尺寸的间隙可能允许通过病变进行传导。本研究的目的是研究不同的间隙几何形状对不连续射频损伤传导的影响。方法和结果-在隔离的兔右室(RV)游离壁标本上建立射频损伤，产生3种不同的病变几何形状的间隙：直形、分叉形和角形(n=10)。有角度的制剂在传导路径内包含2个直角。在1000、400和200ms的起搏周期中，使用光学标测来评估在间隙形成前后通过心肌的双向传导。光学标测后对每种制备方法进行组织学分析。病变形成后，10个直缝标本中9个和10个角度间隙标本中1个双向传导(P
Background-Gaps of sufficient cross-sectional dimensions within linear radiofrequency (RF) lesions may allow conduction through the lesion. The purpose of this study was to examine the effects of different gap geometries on conduction through discontinuous RF lesions.Methods and Results-Radiofrequency lesions were created in isolated, perfused rabbit right ventricular (RV) free wall preparations to produce gaps with 3 different lesion geometries: straight, bifurcated, and angled (n=10 each group). Angled preparations contained 2 right angles within the conduction path. Optical mapping was used to assess bidirectional conduction through the myocardium before and after gap formation during pacing at 1000-, 400-, and 200-ms cycle lengths. Histological analysis was performed on each preparation after optical mapping. After lesion formation, 9 of 10 straight gap preparations and 1 of 10 angled gap preparations demonstrated bidirectional conduction (P