Mantle cell (previously centrocytic) lymphomas express VH genes with no or very little somatic mutations like the physiologic cells of the follicle mantle.
Mantle cell (previously centrocytic) lymphomas express VH genes with no or very little somatic mutations like the physiologic cells of the follicle mantle.
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套细胞（以前是中心细胞）淋巴瘤表达 VH 基因，没有或很少有体细胞突变，如滤泡套的生理细胞。
DOI：
10.1182/blood.v84.2.403.403
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发表时间：
1994
期刊：
影响因子：
20.3
通讯作者：
H. Stein
中科院分区：
文献类型：
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作者：
M. Hummel;J. Tamaru;B. Kalvelage;H. Stein
为了澄清套细胞淋巴瘤 (MCL) 是否与幼稚前生发中心 B 细胞（表达非突变重排 VH 基因）或生发中心来源的记忆 B 细胞（表达突变重排 VH 基因）有关，使用来自 6 个 MCL 的 DNA 进行克隆 IgH 基因重排，进行聚合酶链式反应 (PCR) 扩增，并分析是否存在体细胞突变。为了进行比较，我们的研究纳入了 6 例已知显示非突变重排 VH 基因的 B 慢性淋巴细胞白血病 (B-CLL) 病例和 6 例已知显示突变重排 VH 基因的滤泡中心淋巴瘤 (FCL) 病例。与 6 例 B-CLL 病例一样，6 例 MCL 的 VH 区序列显示没有或很少有体细胞突变，而 6 例 FCL 病例的 VH 序列均高度突变。这表明 MCL 与 B-CLL 一样，源自幼稚前生发中心 B 细胞，并且进一步强调了 MCL 与正常滤泡套区 B 细胞的假设关系，因为最近表明该套区仅或至少大部分由幼稚（未突变）B 细胞组成。
To clarify whether mantle cell lymphomas (MCLs) are related to naive pre-germinal center B cells (expressing nonmutated rearranged VH genes) or to germinal center-derived memory B cells (expressing mutated rearranged VH genes), clonal IgH gene rearrangements using DNA from six MCLs were polymerase chain reaction (PCR)-amplified and analyzed for the presence of somatic mutations. For comparison, six cases of B-chronic lymphocytic leukemia (B-CLL) known to display nonmutated rearranged VH genes and six cases of follicle center lymphomas (FCLs) known to display mutated rearranged VH genes were included in our study. The VH region sequences of the six MCLs showed, like those of the six B-CLL cases, no or very little somatic mutations, in contrast to the VH sequences of the six FCL cases, all of which were highly mutated. This is indicative of MCL, like B-CLL, being derived from naive pre-germinal center B cells and furthermore underscores the postulated relationship of MCLs with the B cells of the normal follicular mantle zone because it has recently been shown that this mantle zone is solely or at least largely composed of naive (nonmutated) B cells.
小淋巴细胞淋巴瘤中 Ig V 区基因表达很少或没有体细胞超突变。
DOI：
--
发表时间：
1989
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Pratt,LF;Rassenti,L;Larrick,J;Robbins,B;Banks,PM;Kipps,TJ
通讯作者：
Kipps,TJ