ESTIMATION OF OPTICAL PATHLENGTH THROUGH TISSUE FROM DIRECT TIME OF FLIGHT MEASUREMENT
ESTIMATION OF OPTICAL PATHLENGTH THROUGH TISSUE FROM DIRECT TIME OF FLIGHT MEASUREMENT
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DOI：
10.1088/0031-9155/33/12/008
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发表时间：
1988-12-01
影响因子：
3.5
通讯作者：
WYATT, J
中科院分区：
文献类型：
--
作者：
DELPY, DT;COPE, M;WYATT, J
在散射介质如组织中的近红外光谱数据的定量需要介质中的光程长度的知识。这现在可以直接从皮秒长度的光脉冲的飞行时间来估计。组织中的光脉冲的Monte Carlo建模已经表明，时间分散的光脉冲的平均值与定量光谱计算中使用的路径长度相关。该结果已在体模材料中得到验证。穿过大鼠头部的路径长度的飞行时间测量给出穿过大鼠头部的路径长度，给出路径长度5.3 ±。0.3乘以头部直径。
Quantitation of near infrared spectroscopic data in a scattering medium such as tissue requires knowledge of the optical pathlength in the medium. This can now be estimated directly from the time of flight of picosecond length light pulses. Monte Carlo modelling of light pulses in tissue has shown that the mean value of the time dispersed light pulse correlates with the pathlength used in quantitative spectroscopic calculations. This result has been verified in a phantom material. Time of flight measurements of pathlength across the rat head give a pathlength across the rat head give a pathlength 5.3 .+-. 0.3 times the head diameter.