Protein-to-creatinine ratio in spot urine samples as a predictor of quantitation of proteinuria
Protein-to-creatinine ratio in spot urine samples as a predictor of quantitation of proteinuria
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DOI：
10.1016/j.cccn.2004.06.019
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发表时间：
2004-12-01
影响因子：
5
通讯作者：
Wang, HY
中科院分区：
文献类型：
--
作者：
Xin, G;Wang, M;Wang, HY
背景：正常人通常会在尿液中排出极少量的蛋白质。持续增加的蛋白质排泄通常是肾脏受损的标志。尿蛋白定量常用于肾脏疾病的诊断、疗效检测和预后评估。我们评价了点尿总蛋白/肌酐比值(P/C)作为预测24小时尿蛋白排泄量的价值。方法：分析头晨和随机尿P/C与24小时尿蛋白排泄量的相关性。结果：对于Ccr<10ml/min的患者，24 h尿蛋白排泄量与24 h尿蛋白排泄量P/C的相关性不显著。对于Ccr和Gt；10ml/min的患者，这种相关性非常显著。随机的尿样也得到了类似的结果。经ROC曲线分析，首次晨尿P/C=0.94g/gcr和2.84g/gcr是检测24 h尿蛋白排泄量分别为1g和3g的最佳临界值。首晨尿P/C值与住院和门诊随机尿P/C值有较好的相关性。结论：在CCR和GT；10ml/min患者中，点尿P/C可替代24 h尿蛋白排泄量。晨尿P/C值明显好于随机尿P/C值，尤其是门诊患者。(C)2004爱思唯尔B.V.保留所有权利。
Background: Normal individuals usually excrete very small amounts of protein in the urine. Persistently increased protein excretion is usually a marker of kidney damage. Quantifying protein in urine is commonly used in the diagnosis of kidney diseases, detection of treatment effects and evaluation of prognosis. We evaluated the use of the total protein-to-creatinine ratio (P/C) in spot urine specimens as a predictor of urine protein excretion in 24-h collections.Methods: The correlation between P/C in first morning and random urine specimens and urinary protein excretion in 24-h collections were analyzed. The cutoff value of P/C in first morning urine specimens for screening urinary protein excretion of I and 3 g in 24-h collections was determined by receiver operating characteristics (ROC) curve.Results: For patients with Ccr less than or equal to 10 ml/min, correlation between the urine protein excretion in 24-h collections and the P/C in first morning urine specimens was not significant. For patients with Ccr > 10 ml/min, the correlation was highly significant. Similar results were obtained for random urine specimens. By ROC curve analysis, the P/C of 0.94 and 2.84 g/gcr in first morning urine specimens represent the best threshold to detect urine protein excretion of 1 and 3 g in 24-h collections, respectively. There is a good correlation between P/C in first morning urine specimens and random urine specimens from inpatients and outpatients. But the P/C in random specimens is significantly higher than that in first morning specimens in outpatients.Conclusion: The P/C in spot urine samples could be used as an alternative to urine protein excretion in 24-h collections in patients with Ccr >10 ml/min. The P/C in first morning urine samples is better than that in random specimens, especially for outpatients. (C) 2004 Elsevier B.V. All rights reserved.