Exercise training improves heart rate variability in older patients with heart failure: a randomized, controlled, single-blinded trial.
Exercise training improves heart rate variability in older patients with heart failure: a randomized, controlled, single-blinded trial.
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DOI：
10.1111/j.1751-7133.2011.00282.x
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发表时间：
2012-07
期刊：
影响因子：
--
通讯作者：
Kitzman DW
中科院分区：
文献类型：
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作者：
Murad K;Brubaker PH;Fitzgerald DM;Morgan TM;Goff DC Jr;Soliman EZ;Eggebeen JD;Kitzman DW
老年心力衰竭（HF）患者心率变异性（HRV）降低是常见的，预示着预后不良。运动训练（ET）已被证明可以改善年轻心衰患者的HRV。然而，ET对老年心衰患者HRV的影响尚不清楚。66名HF患者（36%男性），年龄69±5岁，同时患有保留射血分数（HFPEF）和降低射血分数（HFREF），随机分为16周的监督ET组（ET组）和注意控制组（AC组）。在基线和研究结束后测量两个HRV参数（所有正常RR区间的标准差（SDNN）和正常RR区间连续差异的均方根（RMSSD））。与AC组相比，ET组的SDNN（15.46±5.02 ms， ET组为2.37±2.13 ms, P = 0.016）和RMSSD（17.53±7.83 ms， ET组为1.69±2.63 ms, P = 0.003）均显著增加。这一增长在男女和HF类别中都有体现。ET可改善老年HFREF和HFPEF患者的HRV。
Reduced heart rate variability (HRV) in older patients with heart failure (HF) is common and indicates poor prognosis. Exercise training (ET) has been shown to improve HRV in younger patients with HF. However the effect of ET on HRV in older patients with HF is not known. Sixty-six participants (36% males), age 69±5 years, with HF and both preserved ejection fraction (HFPEF) and reduced ejection fraction (HFREF), were randomly assigned to 16 weeks of supervised ET (ET group) versus attention-control (AC group). Two HRV parameters (the standard deviation of all normal RR intervals (SDNN) and the root mean square of successive differences in normal RR intervals (RMSSD)) were measured at baseline and after completion of the study. When compared with the AC group, the ET group had a significantly greater increase in both SDNN (15.46 ± 5.02 ms in ET versus 2.37 ± 2.13 ms in AC, P = 0.016), and RMSSD (17.53 ± 7.83 ms in ET versus 1.69 ± 2.63 ms in AC, P = 0.003). This increase was seen in both genders and HF categories. ET improves HRV in older patients with both HFREF and HFPEF.