Polydopamine nanoparticles for the treatment of acute inflammation-induced injury
Polydopamine nanoparticles for the treatment of acute inflammation-induced injury
复制标题
聚多巴胺纳米颗粒用于治疗急性炎症引起的损伤
DOI：
10.1039/c8nr00838h
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发表时间：
2018-04-21
期刊：
影响因子：
6.7
通讯作者：
Liu, Zhuang
中科院分区：
文献类型：
--
作者：
Zhao, He;Zeng, Zhandong;Liu, Zhuang
纳米技术介导的抗炎治疗正在成为治疗炎症诱导损伤的新策略。然而，这些抗炎纳米药物的主要障碍之一是它们在体内的潜在毒副作用。在此，我们发现，聚多巴胺（PDA）纳米粒子，其结构和化学性质类似于黑色素，一种天然的生物聚合物，显示出显着的抗炎治疗作用的急性炎症诱导的损伤。富含酚基的PDA可作为自由基清除剂清除炎症反应中产生的活性氧。如通过使用H2O2特异性纳米探针的体内光声成像所揭示的，PDA纳米颗粒显著降低了用H2O2或脂多糖（LPS）攻击的鼠巨噬细胞中的细胞内ROS水平。PDA纳米颗粒的抗炎能力在急性腹膜炎和急性肺损伤（ALI）的鼠模型中得到进一步证明，其中在单剂量PDA治疗后，在PDA治疗的小鼠中观察到ROS产生减少、促炎细胞因子减少、中性粒细胞浸润减弱和肺组织损伤减轻。因此，我们的工作提出了PDA纳米粒子作为一种生物相容性纳米药物的抗炎治疗急性炎症诱导的损伤的巨大希望。
Nanotechnology-mediated anti-inflammatory therapy is emerging as a novel strategy for the treatment of inflammation-induced injury. However, one of the main hurdles for these anti-inflammatory nano-drugs is their potential toxic side effects in vivo. Herein, we uncovered that polydopamine (PDA) nanoparticles with their structure and chemical properties similar to melanin, a natural bio-polymer, displayed a significant anti-inflammation therapeutic effect on acute inflammation-induced injury. PDA with enriched phenol groups functioned as a radical scavenger to eliminate reactive oxygen species (ROS) generated during inflammatory responses. As revealed by in vivo photoacoustic imaging with a H2O2-specific nanoprobe, PDA nanoparticles remarkably reduced intracellular ROS levels in murine macrophages challenged with either H2O2 or lipopolysaccharide (LPS). The anti-inflammatory capacity of PDA nanoparticles was further demonstrated in murine models of both acute peritonitis and acute lung injury (ALI), where diminished ROS generation, reduced proinflammatory cytokines, attenuated neutrophil infiltration, and alleviated lung tissue damage were observed in PDA-treated mice after a single dose of PDA treatment. Our work therefore presents the great promise of PDA nanoparticles as a biocompatible nano-drug for anti-inflammation therapy to treat acute inflammation-induced injury.