Toxoplasma gondii Infection: Relationship With Aggression in Psychiatric Subjects
Toxoplasma gondii Infection: Relationship With Aggression in Psychiatric Subjects
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DOI：
10.4088/jcp.14m09621
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发表时间：
2016-03-01
影响因子：
5.3
通讯作者：
Postolache, Teodor T.
中科院分区：
文献类型：
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作者：
Coccaro, Emil F.;Lee, Royce;Postolache, Teodor T.
目的：研究弓形虫（Toxoplasma gondii，T.弓形虫）是一种原生动物寄生虫，持续存在于宿主组织（包括脑）中，与几种精神疾病和自杀行为有关。我们试图检验潜伏T。弓形虫感染，表现为循环中的弓形虫免疫球蛋白G（IgG）抗体。弓形虫感染与攻击行为的分类和维度指标有关。1991年至2008年期间，从358名患有DSM-5间歇性爆发性障碍（IED）、非IED精神障碍（精神病对照）或无任何精神病诊断证据（健康对照）的成年受试者中收集弓形虫。完成了对攻击性、愤怒和冲动以及状态/特质愤怒、抑郁和焦虑的评估。T.弓形虫血清学阳性状态（IgG > 12 IU）是本研究的主要结局指标。弓形虫血清阳性状态（IgG > 12 IU）与较高的攻击性（P = 0.022）和冲动性（P = 0.05）评分相关。然而，当攻击性和冲动性得分都被控制时，只有血清阳性受试者的攻击性得分更高（P = 0.011）。此外，T.从健康对照组（9.1%和-0.66 +/- 0.05）到精神病对照组（16.7%和-0.27 +/- 0.05）再到IED受试者（21.8%和1.15 +/- 0.06; P = 0.05），弓形虫血清阳性状态和边缘平均+/- SE攻击得分增加。这些发现没有占的存在其他综合征/人格障碍或状态或特征相关的抑郁或焦虑moods.Conclusions：这些数据与以前的研究表明T之间的关系是一致的。弓形虫和自我导向的攻击（即自杀行为），并进一步增加了生物复杂性的冲动攻击无论是从分类和维度的角度。(C)版权所有2016 Physicians Postgraduate Press，Inc.
Objective: Toxoplasma gondii (T. gondii), a protozoan parasite that persists in host tissues, including brain, has been associated with several psychiatric disorders and with suicidal behavior. We sought to test the hypothesis that latent T. gondii infection, as manifest by circulating immunoglobulin G (IgG) antibodies to T. gondii, is associated with both categorical and dimensional measures of aggression.Method: IgG antibodies to T. gondii were collected between 1991 and 2008 from 358 adult subjects with DSM-5 intermittent explosive disorder (IED), non-IED psychiatric disorders (psychiatric controls), or no evidence of any psychiatric diagnosis (healthy controls). Assessments of aggression, anger, and impulsivity, as well as state/trait anger, depression, and anxiety were completed. T. gondii seropositive status (IgG > 12 IU) was the primary outcome measure for this study.Results: T. gondii seropositive status (IgG > 12 IU) was associated with higher aggression (P = .022) and impulsivity (P = .05) scores. When both aggression and impulsivity scores were controlled for, however, only aggression scores were higher in seropositive subjects (P = .011). In addition, T. gondii seropositive status and marginal mean +/- SE aggression scores increased from healthy controls (9.1% and -0.66 +/- 0.05) to psychiatric controls (16.7% and -0.27 +/- 0.05) to subjects with IED (21.8% and 1.15 +/- 0.06; P = .05). These findings were not accounted for by the presence of other syndromal/personality disorders or by states or traits related to depressed or anxious moods.Conclusions: These data are consistent with previous studies suggesting a relationship between T. gondii and self-directed aggression (ie, suicidal behavior) and further add to the biological complexity of impulsive aggression both from a categorical and a dimensional perspective. (C) Copyright 2016 Physicians Postgraduate Press, Inc.