Origin and evolution of the vertebrate leukocyte receptors: the lesson from tunicates
Origin and evolution of the vertebrate leukocyte receptors: the lesson from tunicates
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脊椎动物白细胞受体的起源和进化：被囊动物的教训
DOI：
10.1007/s00251-009-0373-z
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发表时间：
2009
期刊：
影响因子：
3.2
通讯作者：
L. Pasquier
中科院分区：
文献类型：
--
作者：
I. Zucchetti;R. Santis;Simona Grusea;P. Pontarotti;L. Pasquier
免疫球蛋白超家族（IgSF）的两个选定的受体基因、一个CTX/JAM家族成员和一个具有粘附分子特征的脊髓灰质炎病毒受体样连接蛋白可以由玻璃海鞘血细胞（免疫效应器）表达。它们也可以在神经系统（CTX/JAM）和卵巢（nectin）中表达。编码这些受体的基因位于一组基因中，分布在玻璃海鞘4号和10号染色体上，并含有与人（1，3 + X，11，21 + 19 q）或鸟染色体（1，4，24，31）的四分体中存在的基因编码的那些同源的其它IgSF成员，所述四分体包括白细胞受体复合物。有人提出，这四分体是由于两轮的重复，影响了一个单一的前脊椎动物的祖先地区，包含一个原始的白细胞受体复合物参与免疫和其他发育调节功能。
Two selected receptor genes of the immunoglobulin superfamily (IgSF), one CTX/JAM family member, and one poliovirus receptor-like nectin that have features of adhesion molecules can be expressed by Ciona hemocytes, the effectors of immunity. They can also be expressed in the nervous system (CTX/JAM) and in the ovary (nectin). The genes encoding these receptors are located among one set of genes, spread over Ciona chromosomes 4 and 10, and containing other IgSF members homologous to those encoded by genes present in a tetrad of human (1, 3 + X, 11, 21 + 19q) or bird chromosomes (1, 4, 24, 31) that include the leukocyte receptor complex. It is proposed that this tetrad is due to the two rounds of duplication that affected a single prevertebrate ancestral region containing a primordial leukocyte receptor complex involved in immunity and other developmental regulatory functions.
DOI：
10.1073/pnas.94.15.7799
发表时间：
1997-07-22
影响因子：
11.1
作者：
Nei, M;Gu, X;Sitnikova, T
通讯作者：
Sitnikova, T