Cardiovascular profile of the calcium sensitizer EMD 57033 in open-chest anaesthetized pigs with regionally stunned myocardium
Cardiovascular profile of the calcium sensitizer EMD 57033 in open-chest anaesthetized pigs with regionally stunned myocardium
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DOI：
10.1038/sj.bjp.0703231
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发表时间：
2000-04-01
影响因子：
7.3
通讯作者：
Duncker, DJ
中科院分区：
文献类型：
--
作者：
de Zeeuw, S;Trines, SAIP;Duncker, DJ
1钙增敏剂增强收缩功能，但在体外可能损害松弛；这些作用在顿抑心肌和正常心肌中可能有所不同。因此，我们研究了EMD 57033对正常和顿抑猪心肌收缩和舒张期功能的影响。2冠状动脉阻断15分钟和再灌流30分钟造成的心肌顿抑使收缩缩短(SS)(基线13+/-1%)消失，收缩末期弹性(E-ES)从67+/-7下降到47+/-5 mm(-1)(P均<0.05)。
1 Ca2+ sensitizers enhance systolic function, but may impair relaxation in vitro; these effects may differ in stunned and normal myocardium. We therefore studied the effect of EMD 57033 on systolic and diastolic function of normal and stunned porcine myocardium in vivo.2 Myocardial stunning by 15 min coronary occlusion and 30 min reperfusion abolished systolic shortening (SS) (baseline 13+/-1%) and decreased end-systolic elastance (E-es) from 67+/-7 to 47+/-5 mmHg mm(-1) (both P