The pathogenesis of rheumatoid arthritis. A critical assessment of the role of autologous stimulation in the perpetuation of rheumatoid synovitis.
The pathogenesis of rheumatoid arthritis. A critical assessment of the role of autologous stimulation in the perpetuation of rheumatoid synovitis.
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类风湿性关节炎的发病机制。
DOI：
10.1016/s0021-9258(19)47203-7
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
N. Zvaifler
中科院分区：
文献类型：
--
作者：
G. Firestein;N. Zvaifler
目前的类风湿性关节炎模型强调活化T细胞及其产物在滑膜炎发病机制中的作用。支持这一观点的数据在这篇文章中进行了严格审查，并讨论了不一致之处。为了解决这些矛盾，作者提出类风湿性滑膜炎代表了局部自体混合淋巴细胞反应。
Current models for rheumatoid arthritis emphasize the role of activated T cells and their products in the pathogenesis of synovitis. The data supporting this view are critically reviewed in this article and inconsistencies are discussed. To resolve these contradictions, the authors propose that rheumatoid synovitis represents a localized autologous mixed lymphocyte reaction.