Reduction in infection with Plasmodium falciparum one year after the introduction of malaria control interventions on Bioko Island, Equatorial Guinea
Reduction in infection with Plasmodium falciparum one year after the introduction of malaria control interventions on Bioko Island, Equatorial Guinea
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DOI：
10.4269/ajtmh.2006.74.972
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发表时间：
2006-06-01
影响因子：
3.3
通讯作者：
Carter, J
中科院分区：
文献类型：
--
作者：
Kleinschmidt, I;Sharp, B;Carter, J
2003年启动了比奥科岛疟疾控制项目，以大幅减少赤道几内亚比奥科岛的疟疾。干预措施包括在项目的第一年进行室内滞留喷洒。在第二年引入了病例管理和相关措施。2004年和2005年分别对2岁至15岁的儿童进行了两次大型家庭调查和寄生虫病调查，以评估第一年后干预措施的效果。从一家地区医院回顾性收集患者记录，并对干预前和干预后的时间段进行比较分析。恶性疟原虫总体平均感染率从2004年基线时的46%(95%可信区间=40-51%)下降到2005年的31%(95%可信区间=24-40%)(P<；0.001)。当将干预前的12个月与干预后的12个月进行比较时，住院患者中的疟疾病例数量略有减少，但在统计上有显著意义。
The Bioko Island Malaria Control Project was initiated in 2003 to substantially reduce malaria on the island of Bioko in Equatorial Guinea. The intervention consisted of generalized indoor residual spraying during the first year of the project. Case management and related measures were introduced during the second year. Two large household and parasitemia surveys of children 2 to < 15 years of age were carried out in 2004 and 2005, respectively, to assess the effect of the intervention after the first year. Patient records were collected retrospectively from one district hospital and analyzed for a comparison of pre-intervention and post-intervention periods. Overall mean prevalence of P. falciparum infection reduced from 46% (95% confidence interval [CI] = 40-51%) at baseline in 2004 to 31% (95% CI = 24-40%) in 2005 (P < 0.001.). When the 12-month pre-intervention period was compared with the 12-month post-intervention period, there was a modest but statistically significant reduction in the number of malaria cases among hospital patients.