Time-to-Progression of NSCLC from Early to Advanced Stages: An Analysis of data from SEER Registry and a Single Institute.
Time-to-Progression of NSCLC from Early to Advanced Stages: An Analysis of data from SEER Registry and a Single Institute.
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DOI：
10.1038/srep28477
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发表时间：
2016-06-27
影响因子：
4.6
通讯作者：
Hu J
中科院分区：
文献类型：
--
作者：
Yuan P;Cao JL;Rustam A;Zhang C;Yuan XS;Bao FC;Lv W;Hu J
癌症通过各个阶段进展所需的平均时间可以反映在每个疾病阶段诊断的患者的平均年龄中。为了估计非小细胞肺癌（NSCLC）通过不同肿瘤、淋巴结和转移（TNM）阶段和大小进展所需的时间，我们比较了来自监测、流行病学和最终结果（SEER）癌症登记数据库和我们研究所的45904例不同阶段和肿瘤大小的NSCLC患者的平均校正年龄。年龄的多元线性回归模型生成调整各种因素。与IIIB期癌症患者相比，高加索人、非洲裔美国人和亚洲人IA期癌症患者平均分别年轻0.8、1.0和1.38岁（p < 0.001）。T1a癌症患者的平均年龄分别比T3癌症患者年轻0.84、0.92和1.21岁（p < 0.001）。肿瘤直径大于8 cm的患者比肿瘤直径小于1 cm的患者平均年长0.85岁（p < 0.001），其中白人的年龄跨度最短（0.79岁，P < 0.001）。总之，NSCLC从早期到晚期的进展时间因种族而异，高加索患者的肿瘤进展速度比非洲裔美国人和亚洲患者更快。
The average time required for cancers to progress through stages can be reflected in the average age of the patients diagnosed at each stage of disease. To estimate the time it takes for non-small-cell lung cancer (NSCLC) to progress through different tumor, node and metastasis (TNM) stages and sizes, we compared the mean adjusted age of 45904 NSCLC patients with different stages and tumor sizes from Surveillance, Epidemiology and End Results (SEER) cancer registry database and our institute. Multiple-linear-regression models for age were generated adjusting for various factors. Caucasian, African-American and Asian patients with stage IA cancers were on average 0.8, 1.0 and 1.38 adjusted years younger, respectively, than those with stage IIIB cancers (p < 0.001). And these with T1a cancers were on average 0.84, 0.92 and 1.21 adjusted years younger, respectively, than patients with T3 cancers (p < 0.001). Patients with tumors measuring larger than 8 cm in diameter were on average 0.85 adjusted years older than these with tumors smaller than 1 cm (p < 0.001), with Caucasian demonstrating the shortest age span (0.79 years, P < 0.001). In conclusion, the time-to-progression of NSCLC from early to advanced stages varied among ethnicities, Caucasian patients demonstrating a more rapid progression nature of tumor than their African-American and Asian counterparts.