Cutting edge:: CD8+ effector T cells reject tumors by direct antigen recognition but indirect action on host cells
Cutting edge:: CD8+ effector T cells reject tumors by direct antigen recognition but indirect action on host cells
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DOI：
10.4049/jimmunol.170.9.4427
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发表时间：
2003-05-01
影响因子：
4.4
通讯作者：
Blankenstein, T
中科院分区：
文献类型：
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作者：
Schüler, T;Blankenstein, T
CD8(+)效应T细胞通过监测恶性细胞表面是否存在与MHC I类分子结合的肿瘤衍生肽来识别恶性细胞。此外，肿瘤来源的Ag可以通过APC交叉呈递给CD8(+)效应T细胞。 CD8(+) T 细胞产生的 IFN-γ 通常对于肿瘤排斥至关重要。然而，目前尚不清楚：1）CD8+T细胞是否响应肿瘤细胞或APC上的Ag识别而分泌IFN-γ；2）IFN-γ是否通过作用于宿主或肿瘤细胞来介导其抗肿瘤作用。我们在这项研究中表明，CD8(+)效应T细胞可以排斥骨髓嵌合小鼠中的肿瘤，而骨髓嵌合小鼠不能通过骨髓来源的APC交叉呈递Ag，并且肿瘤排斥需要宿主细胞表达IFN-gammaR。 CD8(+)效应T细胞一起直接识别肿瘤细胞上的Ag，并且这种识别足以通过作用于宿主细胞的IFN-γ来排斥肿瘤。
CD8(+) effector T cells recognize malignant cells by monitoring their surface for the presence of tumor-derived-peptides bound to MHC class I molecules. In addition, tumor-derived-Ags can be cross-presented to CD8(+) effector T cells by APCs. IFN-gamma production by CD8(+) T cells is often critical for tumor rejection. However, it remained unclear whether 1) CD8(+) T cells secrete IFN-gamma in response to Ag recognition on tumor cells or APCs and 2) whether IFN-gamma mediates its antitumor effect by acting on host or tumor cells. We show in this study that CD8(+) effector T cells can reject tumors in bone marrow-chimeric mice incapable of cross-presenting Ag by bone marrow-derived APCs and that tumor rejection required host cells to express IFN-gammaR. Together, CD8(+) effector T cells recognize Ag directly on tumor cells, and this recognition is sufficient to reject tumors by IFN-gamma acting on host cells.