Pathway-related modules involved in the application of sevoflurane or propofol in off-pump coronary artery bypass graft surgery.
Pathway-related modules involved in the application of sevoflurane or propofol in off-pump coronary artery bypass graft surgery.
复制标题
涉及七氟醚或丙泊酚在非体外循环冠状动脉搭桥手术中应用的通路相关模块。
DOI：
10.3892/etm.2017.4504
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发表时间：
2017-07
影响因子：
2.7
通讯作者：
Zhang C
中科院分区：
文献类型：
--
作者：
Bu X;Wang B;Wang Y;Wang Z;Gong C;Qi F;Zhang C
非体外循环冠状动脉旁路移植术（CABG）是近年来出现的一种避免体外循环后遗症的方法，包括全身炎症反应、凝血功能障碍和多器官功能障碍。目前，气体麻醉、七氟醚麻醉、静脉麻醉和丙泊酚麻醉在冠状动脉旁路移植术中已被广泛应用。为了进一步从基因水平上了解这些麻醉药的作用机制，本研究基于共表达网络进行了通路相关模块分析。这是为了确定在应用七氟烷或丙泊酚之前和之后接受非体外循环CABG手术的冠状动脉疾病患者中的重要通路。在七氟烷组和丙泊酚组中分别获得了269个和129个差异表达基因。通过京都基因百科全书和基因组通路分析，七氟烷组和丙泊酚组分别获得了8条和7条通路（P<0.05）。最后，七氟烷和丙泊酚组分别获得8个和7个通路相关模块。此外，两组中补体和凝血级联途径相关模块的平均程度最高。据推测，在冠状动脉旁路移植术中，麻醉药可能通过激活补体和凝血系统而具有一定的心脏保护作用。
Off-pump coronary artery bypass graft (CABG) surgery has recently emerged as a means to avoid the sequelae of extracorporeal circulation, including the whole-body inflammatory response, coagulation disorders and multiple organ dysfunction. At present, gas anesthesia, sevoflurane and intravenous anesthesia and propofol have been widely used during the CABG. To further understand the underlying mechanisms of these anesthetics on the gene level, the present study conducted pathway-related module analysis based on a co-expression network. This was performed in order to identify significant pathways in coronary artery disease patients who had undergone off-pump CABG surgery before and after applying sevoflurane or propofol. A total of 269 and 129 differentially expressed genes were obtained in the sevoflurane and propofol groups, respectively. In total, eight and seven pathways (P<0.05) in the sevoflurane and propofol groups were separately obtained via Kyoto Encyclopedia of Genes and Genome pathway analysis. Finally, eight and seven pathway-related modules in the sevoflurane and propofol groups were obtained, respectively. Furthermore, the mean degree of complement and coagulation cascades pathway-related module in both of the groups was the highest. It was predicted that during the CABG, the anesthetics might activate the complement and coagulation systems in order to possess some cardioprotective properties.