Association between particulate matter concentration and symptoms of atopic dermatitis in children living in an industrial urban area of South Korea
Association between particulate matter concentration and symptoms of atopic dermatitis in children living in an industrial urban area of South Korea
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DOI：
10.1016/j.envres.2017.10.030
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发表时间：
2018-01-01
影响因子：
8.3
通讯作者：
Kim, Yangho
中科院分区：
文献类型：
--
作者：
Oh, Inbo;Lee, Jiho;Kim, Yangho
简介：增加暴露于颗粒物（PM）似乎增加了特应性疾病和过敏性致敏的发展。本研究评估了生活在工业城市地区的儿童每日直径小于10pm的PM （PM10）和PM2.5水平与特应性皮炎（AD）症状之间的关系。方法：采用光学粒子计数器对韩国蔚山大型工业园区附近的两所幼儿园室内PM10和PM2.5浓度进行了为期6个月的测量（2012年5月至10月和2013年10月）。来自这些幼儿园的21名阿尔茨海默病儿童被招募，并在同一时期每天观察阿尔茨海默病的症状。室内和室外的PM浓度被用来根据时间活动模式估计PM暴露。结果：PM10和PM2.5浓度分析显示，室内和室外PM10水平在每6个月期间变化相似。此外，室内PM2.5浓度与室外环境PM10浓度高度相关。相关分析还表明，AD症状加重与PM10和PM2.5日均暴露量呈正相关。基于广义线性混合模型（GLMM）， PM暴露与AD症状加重显著相关，PM2.5每增加10 μ g/m3，最大调整优势比（aOR）为1.399 （95% CI: 1.216-1.610）。讨论：我们的研究结果表明，短期暴露于PM可使生活在工业城市地区的幼儿AD恶化。PM2.5对AD症状加重的影响强于PM10。
Introduction: Increased exposure to particulate matter (PM) appears to increase the development of atopic diseases and allergic sensitization. This study evaluated the association between daily levels of PM with diameters less than 10 pm (PM10) and PM2.5 and symptoms of atopic dermatitis (AD) in children living in an industrial urban area.Methods: Indoor PM10 and PM2.5 concentrations were measured with an optical particle counter in two preschools near large industrial complexes in Ulsan, South Korea during two 6 -month periods (May October of 2012 and 2013). Twenty-one children with AD from these preschools were enrolled and observed daily for AD symptoms during the same periods. Indoor and outdoor PM concentrations were used to estimate PM exposure based on time activity patterns.Results: Analysis of PM10 and PM2.5 concentrations showed that indoor and outdoor PM10 levels varied similarly throughout each 6 -month period. In addition, indoor concentration of PM2.5 had high correlation with ambient outdoor concentration of PM10. Correlation analysis also indicated a significant positive correlation between the exacerbation of AD symptoms and daily mean exposure to PM10 and PM2.5. Based on a generalized linear mixed model (GLMM), PM exposure was significantly associated with the exacerbation of AD symptoms, with a maximum adjusted odds ratio (aOR) of 1.399 for a 10 mu g/m3 increase of PM2.5 (95% CI: 1.216-1.610).Discussion: Our findings suggest that short-term exposure to PM can exacerbate AD in young children living in an industrial urban area. PM2.5 had a stronger effect than PM10 on exacerbation of AD symptoms.