Effective chromosome pairing requires chromatin remodeling at the onset of meiosis
Effective chromosome pairing requires chromatin remodeling at the onset of meiosis
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DOI：
10.1073/pnas.0801521105
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发表时间：
2008-04-22
影响因子：
11.1
通讯作者：
Moore, Graham
中科院分区：
文献类型：
--
作者：
Colas, Isabelle;Shaw, Peter;Moore, Graham
在减数分裂过程中，同源染色体（同系物）相互识别，然后紧密结合。利用具有大染色体的物种的研究揭示，在这种紧密结合之前，在减数分裂开始时，染色质被重塑。然而，关于重塑对配对的影响知之甚少。我们在这里表明，在小麦同源染色质重塑只能发生，如果他们是相同的或几乎相同的。此外，不能进行重塑导致同源物之间的配对减少。因此，减数分裂开始时的染色质重塑使染色体能够有效地配对和重组。
During meiosis, homologous chromosomes (homologues) recognize each other and then intimately associate. Studies exploiting species with large chromosomes reveal that chromatin is remodeled at the onset of meiosis before this intimate association. However, little is known about the effect the remodeling has on pairing. We show here in wheat that chromatin remodeling of homologues can only occur if they are identical or nearly identical. Moreover, a failure to undergo remodeling results in reduced pairing between the homologues. Thus, chromatin remodeling at the onset of meiosis enables the chromosomes to become competent to pair and recombine efficiently.