The association between cannabis use and risk of non-medical pain reliever misuse onset among young adults in a legal cannabis context.
The association between cannabis use and risk of non-medical pain reliever misuse onset among young adults in a legal cannabis context.
复制标题
在合法大麻背景下，大麻使用与年轻人非医疗止痛药误用风险之间的关联。
DOI：
10.1016/j.addbeh.2023.107711
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发表时间：
2023
影响因子：
4.4
通讯作者：
Guttmannova,Katarina
中科院分区：
文献类型：
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作者：
Rhew,IsaacC;Le,ViT;Ramirez,JasonJ;Fleming,CharlesB;Kilmer,JasonR;Delawalla,MirandaLM;Hultgren,BrittneyA;Lee,ChristineM;Larimer,MaryE;Guttmannova,Katarina
背景人们对大麻使用和止痛药滥用之间的潜在关系知之甚少。这项研究调查了华盛顿州 (WA) 年轻人中非医用和医用大麻的使用与非医用止痛药滥用之间的关系，该州非医用大麻是合法的。方法数据来自对居住在 WA 的 18-25 岁成年人进行的一项队列序贯研究。对 2014 年、2015 年和 2016 年招募的队列进行了四项年度调查。基线时未报告非医疗止痛药滥用的参与者被纳入离散时间生存分析 (N = 4,236)。根据基线非医疗和医用大麻使用情况，估计三年内任何给定随访年份新发非医疗止痛药滥用的比值比 (OR)。结果当单独包含在模型中时，基线时的非医疗和医用大麻使用与非医疗止痛药滥用风险增加相关，并根据人口特征以及过去一年的吸烟和饮酒进行调整（非医疗 OR = 5.27；95%） CI：3.28，8.48；医学 OR = 2.21；95% CI：1.39，3.52）。包括模型中的两种使用形式，非医疗和医疗大麻使用与非医疗止痛药滥用发作之间的关联仍然存在（非医疗 OR = 4.64；95% CI：2.88，7.49；医疗 OR = 1.65；95% CI：1.04，2.62）。 结论 尽管声称大麻使用可能会减少阿片类药物的使用和相关危害，研究结果表明，大麻的使用，包括医疗用途，可能不会起到保护作用，反而可能会增加非医疗止痛药滥用的风险。
BackgroundLittle is known about the prospective relationship between cannabis use and pain reliever misuse. This study examined associations of non-medical and medical cannabis use with onset of non-medical pain reliever misuse among young adults in Washington State (WA), where non-medical cannabis is legal.MethodsData were from a cohort-sequential study of adults 18–25 residing in WA. Four annual surveys were used from cohorts recruited in 2014, 2015, and 2016. Participants who had not reported non-medical pain reliever misuse at baseline were included in discrete time survival analyses (N= 4,236). Odds ratios (ORs) were estimated for new onset of non-medical pain reliever misuse in any given follow-up year over the course of three years according to baseline non-medical and medical cannabis use.ResultsWhen included separately in models, non-medical and medical cannabis use at baseline were associated with increased risk of non-medical pain reliever misuse adjusting for demographic characteristics as well as past year cigarette use and alcohol use (non-medical OR = 5.27; 95 % CI: 3.28, 8.48; medical OR = 2.21; 95 % CI: 1.39, 3.52). Including both forms of use in the model, associations of non-medical and medical cannabis use with non-medical pain reliever misuse onset remained (non-medical OR = 4.64; 95 % CI: 2.88, 7.49; medical OR = 1.65; 95 % CI: 1.04, 2.62).ConclusionsDespite claims that cannabis use may reduce opioid use and related harms, findings suggest that cannabis use, including medical use, may not be protective, but instead may increase risk for non-medical pain reliever misuse.