A DNA-SEQUENCE SPECIFIC FOR FOREST FORM ONCHOCERCA-VOLVULUS
A DNA-SEQUENCE SPECIFIC FOR FOREST FORM ONCHOCERCA-VOLVULUS
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DOI：
10.1038/327415a0
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发表时间：
1987-06-04
期刊：
影响因子：
64.8
通讯作者：
WILLIAMS, PN
中科院分区：
文献类型：
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作者：
ERTTMANN, KD;UNNASCH, TR;WILLIAMS, PN
盘尾丝虫病或河盲症是由盘尾丝虫感染引起的，盘尾丝虫是一种丝虫寄生虫，在非洲和拉丁美洲感染了大约4000万人。对非洲盘尾丝虫病的流行病学1、临床2、昆虫学3、4和血清学5研究提出了这样一种假设，即盘尾丝虫在森林和热带草原中以不同的形式存在。目前还不确定这些差异是否是由于O.扭转本身，或表观遗传因素，如宿主种群的差异。到目前为止，森林和稀树草原种群之间没有基本的生化差异。尽管同工酶研究表明森林和热带稀树草原种群之间存在等位基因频率的差异，但是已经发现了肠扭转6，7。在这里，我们描述了分离的DNA序列，似乎是特定的森林形式ofO。扭转，第一个迹象之间的基本遗传差异草原和森林的形式。
Onchocerciasis, or river blindness, is caused by infection withOnchocerca volvulus, a filarial parasite which infects about 40 million people in Africa and Latin America. Epidemiological1, clinical2, entomological3,4and serological5studies of African Onchocerciasis led to the hypothesis thatOnchocerca volvulusexists in different forms in the forest and savannah. It is uncertain if these differences are due to genetic differences withinO. volvulusitself, or to epigenetic factors, such as differences in the host populations. To date no basic biochemical differences between the forest and savannah populations ofO. volvulushas been found, although isoenzyme studies have shown that differences in allele frequency between forest and savannah populations exist6,7. Here we describe the isolation of a DNA sequence that seems to be specific for the forest form ofO. volvulus, the first indication of a basic genetic difference between the savannah and forest forms.