Epidemiologic and clinical characteristics of 91 hospitalized patients with COVID-19 in Zhejiang, China: a retrospective, multi-centre case series
Epidemiologic and clinical characteristics of 91 hospitalized patients with COVID-19 in Zhejiang, China: a retrospective, multi-centre case series
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DOI：
10.1093/qjmed/hcaa089
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发表时间：
2020-07-01
影响因子：
13.3
通讯作者：
Chen, X-M
中科院分区：
文献类型：
--
作者：
Qian, G-Q;Yang, N-B;Chen, X-M
背景：近年来的研究主要集中在新型冠状病毒病2019 （COVID-19）的初步临床和流行病学特征上，主要揭示的是湖北省武汉市的情况。目的：本研究旨在揭示中国浙江省武汉市以外地区新冠肺炎患者的流行病学和临床特征。设计：本研究为回顾性病例系列研究。方法：收集浙江省5家医院收治的新冠肺炎实验室确诊病例88例，临床确诊病例3例。数据收集于2020年1月20日至2020年2月11日。结果与讨论：91例患者中，实验室确诊88例（96.70%），咽拭子标本检测为SARS-Cov-2阳性，临床确诊3例（3.30%）。患者年龄中位数为50（36.5-57）岁，女性占59.34%。本组病例中，40例（43.96%）为本地感染病例，31例（34.07%）为武汉/湖北感染病例，8例（8.79%）为武汉人接触病例，11例（12.09%）为同机未发现传染源的旅客。特别是在宁波市，60.52%的病例可追溯到寺庙举办的活动。最常见的症状为发热（71.43%）、咳嗽（60.44%）和乏力（43.96%）。潜伏期中位数为6天（四分位数间3-8天），从首次就诊到确诊的中位数时间为1（1-2）天。胸部计算机断层扫描显示，67.03%的病例有双侧肺炎。结论：社会活动聚集性、家庭聚集性、伴飞性是浙江省新型冠状病毒感染的主要途径。
Background: Recent studies have focused on initial clinical and epidemiological characteristics of the coronavirus disease 2019 (COVID-19), which is the mainly revealing situation in Wuhan, Hubei. Aim: This study aims to reveal more data on the epidemiological and clinical characteristics of COVID-19 patients outside of Wuhan, Zhejiang, China.Design: This study was a retrospective case series.Methods: Eighty-eight cases of laboratory-confirmed and three cases of clinically confirmed COVID-19 were admitted to five hospitals in Zhejiang province, China. Data were collected from 20 January 2020 to 11 February 2020.Results and discussion: Of all 91 patients, 88 (96.70%) were laboratory-confirmed COVID-19 with throat swab samples that tested positive for SARS-Cov-2, three (3.30%) cases were clinically diagnosed. The median age of the patients was 50 (36.5-57) years, and female accounted for 59.34%. In this sample, 40 (43.96%) patients had contracted the disease from local cases, 31 (34.07%) patients had been to Wuhan/Hubei, eight (8.79%) patients had contacted with people from Wuhan, and 11 (12.09%) patients were diagnosed after having flown together in the same flight with no passenger that could later be identified as the source of infection. In particular within the city of Ningbo, 60.52% cases can be traced back to an event held in a temple. The most common symptoms were fever (71.43%), cough (60.44%) and fatigue (43.96%). The median of incubation period was 6 (interquartile range 3-8) days and the median time from the first visit to a doctor to the confirmed diagnosis was 1 (1-2) days. According to the chest computed tomography scans, 67.03% cases had bilateral pneumonia.Conclusions: Social activity cluster, family cluster and flying alongside with persons already infected with COVID-19 were how people got infected with COVID-19 in Zhejiang.