Clinical Features and Outcomes of Bloodstream Infections Caused by New Delhi Metallo-β-Lactamase-Producing Enterobacterales During a Regional Outbreak
Clinical Features and Outcomes of Bloodstream Infections Caused by New Delhi Metallo-β-Lactamase-Producing Enterobacterales During a Regional Outbreak
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DOI：
10.1093/ofid/ofaa011
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发表时间：
2020-02-01
影响因子：
4.2
通讯作者：
Menichetti, Francesco
中科院分区：
文献类型：
--
作者：
Falcone, Marco;Tiseo, Giusy;Menichetti, Francesco
关于新德里金属β-内酰胺酶（NDM）菌血症的数据有限。对40例NDM菌血症患者的血液分离株进行了抗生素敏感性和全基因组测序研究。NDM菌血症的30天死亡率很高。在大多数情况下，氨曲南-阿维巴坦在体外具有活性。头孢他啶-阿维巴坦联合氨曲南可能是一种可行的治疗选择。
Limited data about New Delhi metallo-beta-lactamase (NDM) bacteremia are available. Blood isolates from 40 patients with NDM bacteremia were studied for antibiotic susceptibility and whole-genomic sequencing. NDM bacteremia has high 30-day mortality. In most cases, aztreonam-avibactam is active in vitro. Ceftazidime-avibactam plus aztreonam may represent a feasible therapeutic option.