Chemical routes to poly(β-malic acid) and potential applications of this water-soluble bioresorbable poly(β-hydroxy alkanoate)
Chemical routes to poly(β-malic acid) and potential applications of this water-soluble bioresorbable poly(β-hydroxy alkanoate)
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DOI：
10.1016/s0141-3910(97)00158-4
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发表时间：
1998-01-01
影响因子：
5.9
通讯作者：
Vert, M
中科院分区：
文献类型：
--
作者：
Vert, M
介绍了聚（β - 苹果酸）及其衍生物的主要合成路线。其中大多数是基于β - 取代的β - 内酯化合物的开环聚合。然而，通过苄基保护基的部分氢解或在预先形成的多元羧酸聚合物上进行偶联的化学修饰，可以得到其他衍生物，例如具有各种侧基（包括药物或交联剂）的共聚物和三元共聚物。沿着聚合物主链存在手性中心极大地增加了可生成的不同聚合物结构的数量。回顾了这种聚（羧酸）及其衍生物的主要性质，并用于讨论基于苹果酸的聚酯的主要潜在应用。（C）1998爱思唯尔科学有限公司。保留所有权利。
The main routes of synthesis to poly(beta-malic acid) and to its derivatives are presented. Most of them are based on the ring-opening polymerization of beta-substituted beta-lactonic compounds. However, chemical modifications by partial hydrogenolysis of benzyl protecting groups or by coupling on the pre-formed polycarboxylic acid polymer give access to other derivatives such as copolymers and terpolymers with various pendent groups including drugs or cross-linking agents. The presence of centers of chirality along the polymer backbone enlarges very much the number of different polymer structures that can be generated. The main properties of this poly(carboxylic acid) and of its derivatives are recalled and are used to discuss the main potential applications of malic acid-based polyesters. (C) 1998 Elsevier Science Limited. All rights reserved.