Age-dependent changes in particulate and soluble guanylyl cyclase activities in urinary tract smooth muscle.
Age-dependent changes in particulate and soluble guanylyl cyclase activities in urinary tract smooth muscle.
复制标题
泌尿道平滑肌颗粒和可溶性鸟苷酸环化酶活性的年龄依赖性变化。
DOI：
10.1023/a:1006823611864
复制
发表时间：
1997
影响因子：
4.3
通讯作者：
Weiss,RM
中科院分区：
文献类型：
--
作者：
Wheeler,MA;Pontari,M;Dokita,S;Nishimoto,T;Cho,YH;Hong,KW;Weiss,RM
Regional and age specific differences are observed in the sodium nitroprusside induced relaxation responses in the urinary tract. To clarify these differences, guanylyl cyclase activity is assayed in particulate and soluble fractions from the ureter, bladder dome, and urethra of young (11-18 days), adult (90-100 days), and old adult (2-3 years) guinea pigs. The rank order of soluble guanylyl cyclase activities is urethra = ureter > bladder dome with the largest decreases with aging occurring in the bladder. Atrial natriuretic factor (10-7 M) increases particulate guanylyl cyclase activity in the three tissues at all ages tested, with the activity being highest in the ureter. ATP (0.5 mM) activates particulate guanylyl cyclase in the ureter, bladder and urethra of old adult guinea pigs, and enhances atrial natriuretic factor induced activation of particulate guanylyl cyclase in all tissues and at all ages tested. The higher levels of soluble guanylyl cyclase activity in the urethra and ureter compared to the bladder parallel sodium nitroprusside induced relaxation in these tissues.
