Epithelioid malignant peripheral nerve sheath tumour in a dog
Epithelioid malignant peripheral nerve sheath tumour in a dog
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DOI：
10.1016/j.jcpa.2003.12.012
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发表时间：
2004-07-01
影响因子：
0.8
通讯作者：
Flores, JM
中科院分区：
文献类型：
--
作者：
García, P;Sánchez, B;Flores, JM
恶性周围神经鞘肿瘤的异常形态变异，其中细胞主要表现为上皮形态，被诊断为狗。动物有进行性共济失调史。尸检显示腰下区浸润性生长，侵犯L1和L2椎体；肾、肝、肺均可见肿物。组织学上，皮下肿块由密集的纺锤形细胞组成，呈束状排列。内部肿块由上皮样细胞组成，呈结节状排列。免疫组化结果显示，皮下肿块梭形细胞S-100阳性，内部生长的上皮样细胞S-100免疫反应性弱。(C) 2004 Elsevier Ltd.版权所有。
An unusual morphological variant of malignant peripheral nerve sheath tumour, in which the cells exhibited a predominantly epithelial morphology, was diagnosed in a dog. The animal had a history of progressive ataxia. Post-mortem examination revealed an infiltrative growth in the sublumbar region, encroaching on the L1 and L2 vertebral bodies; additional masses were observed in the kidneys, liver and lungs. Histologically, the subcutaneous mass was composed of a dense population of spindle-shaped cells arranged in fascicles. The internal masses were composed of epithelioid cells arranged in a nodular pattern. Immunohistochemically, the spindle-shaped cells of the subcutaneous mass were positive for S-100, and the epithelioid cells of the internal growths exhibited weak S-100 immunoreactivity. (C) 2004 Elsevier Ltd. All rights reserved.