MEG-based neurofeedback for hand rehabilitation.
MEG-based neurofeedback for hand rehabilitation.
复制标题
DOI：
10.1186/s12984-015-0076-7
复制
发表时间：
2015-09-22
影响因子：
5.1
通讯作者：
Collinger JL
中科院分区：
文献类型：
--
作者：
Foldes ST;Weber DJ;Collinger JL
以生物相关和直观的方式提供运动相关脑活动的神经反馈（NF）可以最大限度地提高脑机接口（BCI）用于促进治疗可塑性的效用。我们提出了一个脑机接口能够提供直观和直接的控制基于视频的把握。利用脑磁图（MEG）的高时间和空间分辨率，我们记录的感觉运动节律（SMR）的把握或休息的意图调制。SMR调制控制人手的停止运动视频的抓握孔径。所显示的手抓握位置被逐渐驱动朝向闭合或打开状态，并且要求受试者保持目标位置一段时间，该时间被调整以改变任务难度。我们证明，三个人完全手麻痹，由于脊髓损伤（SCI）能够保持大脑控制的关闭和打开虚拟手，平均63%的成功率，这是显着高于平均机会率19%。这种性能水平是在没有预训练和不到4分钟的校准的情况下实现的。此外，在1.96 ± 0.15 s内达到成功抓取目标。受试者在大约30分钟内（不包括休息时间）进行了200次脑对照试验。三名参与者中有两名在SMR方面表现出显着改善，这表明他们已经学会了在一次NF中改变他们的大脑活动。这项研究证明了基于脑磁图的脑机接口系统的实用性，提供现实的，有效的，集中的NF与瘫痪的个人使用NF诱导神经可塑性的目标。
Providing neurofeedback (NF) of motor-related brain activity in a biologically-relevant and intuitive way could maximize the utility of a brain-computer interface (BCI) for promoting therapeutic plasticity. We present a BCI capable of providing intuitive and direct control of a video-based grasp. Utilizing magnetoencephalography’s (MEG) high temporal and spatial resolution, we recorded sensorimotor rhythms (SMR) that were modulated by grasp or rest intentions. SMR modulation controlled the grasp aperture of a stop motion video of a human hand. The displayed hand grasp position was driven incrementally towards a closed or opened state and subjects were required to hold the targeted position for a time that was adjusted to change the task difficulty. We demonstrated that three individuals with complete hand paralysis due to spinal cord injury (SCI) were able to maintain brain-control of closing and opening a virtual hand with an average of 63 % success which was significantly above the average chance rate of 19 %. This level of performance was achieved without pre-training and less than 4 min of calibration. In addition, successful grasp targets were reached in 1.96 ± 0.15 s. Subjects performed 200 brain-controlled trials in approximately 30 min excluding breaks. Two of the three participants showed a significant improvement in SMR indicating that they had learned to change their brain activity within a single session of NF. This study demonstrated the utility of a MEG-based BCI system to provide realistic, efficient, and focused NF to individuals with paralysis with the goal of using NF to induce neuroplasticity.