Among Vitamin B12 Deficient Older People, High Folate Levels are Associated with Worse Cognitive Function: Combined Data from Three Cohorts
Among Vitamin B12 Deficient Older People, High Folate Levels are Associated with Worse Cognitive Function: Combined Data from Three Cohorts
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DOI：
10.3233/jad-131265
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发表时间：
2014-01-01
影响因子：
4
通讯作者：
Watters, David A.
中科院分区：
文献类型：
--
作者：
Moore, Eileen M.;Ames, David;Watters, David A.
背景资料：叶酸强化食品旨在减少出生时患有神经管缺陷的婴儿数量，但当维生素B12水平不足时，与认知障碍有关。鉴于老年人维生素B12水平普遍偏低，以及食品强化计划在全球范围内的部署，需要对认知功能障碍、维生素B12和叶酸之间的关系进行调查。目的：探讨血清维生素B12、红细胞叶酸和认知功能障碍之间的关系。在两项调查认知障碍的研究中，收集了1，354名受试者的数据，以及2001年至2011年间在澳大利亚东南部巴旺地区接受记忆问题评估或管理的患者的数据。纳入了在认知测试六个月内进行维生素B12和红细胞叶酸血液测量的合格受试者。排除患有中风或阿尔茨海默病以外的神经退行性疾病的受试者。简易精神状态检查评分为
Background: Folate fortification of food aims to reduce the number of babies born with neural tube defects, but has been associated with cognitive impairment when vitamin B12 levels are deficient. Given the prevalence of low vitamin B12 levels among the elderly, and the global deployment of food fortification programs, investigation of the associations between cognitive impairment, vitamin B12, and folate are needed.Objective: To investigate the associations of serum vitamin B12, red cell folate, and cognitive impairment.Methods: Data were collected on 1,354 subjects in two studies investigating cognitive impairment, and from patients attending for assessment or management of memory problems in the Barwon region of south eastern Australia between 2001 and 2011. Eligible subjects who had blood measurements of vitamin B12 and red cell folate taken within six months of cognitive testing were included. Subjects with stroke or neurodegenerative diseases other than Alzheimer's disease were excluded. A Mini-Mental State Examination score of