Abnormalities of myelination in schizophrenia detected in vivo with MRI, and post-mortem with analysis of oligodendrocyte proteins
Abnormalities of myelination in schizophrenia detected in vivo with MRI, and post-mortem with analysis of oligodendrocyte proteins
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DOI：
10.1038/sj.mp.4001337
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发表时间：
2003-01-01
影响因子：
11
通讯作者：
Honer, WG
中科院分区：
文献类型：
--
作者：
Flynn, SW;Lang, DJ;Honer, WG
精神分裂症发生在脑成熟后期，而髓鞘形成仍在继续。在本研究中，我们使用MRI和T2弛豫分析来测量精神分裂症患者髓磷脂水组分。精神分裂症患者（n = 30）与健康人（n = 27）相比，整体白质髓磷脂水含量降低12% (P = 0.031)，其中胼胝体左膝影响最显著（降低36%，P = 0.002）。首发患者（P = 0.035）和慢性患者（P = 0.011）均有左膝前移位。在健康受试者中，总白质和额叶白质中的髓鞘水分数随着年龄和受教育年限的增加而增加，表明正在发育成熟。在精神分裂症患者中，两种关系均无统计学意义。对前额叶皮层的尸检研究表明，精神分裂症患者两种少突胶质细胞相关蛋白的免疫反应性降低（2',3'-环核苷酸3'-磷酸二酯酶降低33%，P = 0.05；髓磷脂相关糖蛋白降低27%，P = 0.14）。精神分裂症患者髓鞘形成受损可能导致神经连通性异常和持续性功能障碍。
Schizophrenia unfolds during the late period of brain maturation, while myelination is still continuing. In the present study, we used MRI and T2 relaxation analysis to measure the myelin water fraction in schizophrenia. In schizophrenia ( n = 30) compared with healthy subjects ( n = 27), overall white matter showed 12% lower myelin water fraction ( P = 0.031), with the most prominent effects on the left genu of the corpus callosum (36% lower, P = 0.002). The left anterior genu was affected in both first-episode (P = 0.035) and chronic patients (P = 0.011). In healthy subjects, myelin water fraction in total white matter and in frontal white matter increased with age, and with years of education, indicating ongoing maturation. In patients with schizophrenia, neither relation was statistically significant. Post-mortem studies of anterior frontal cortex demonstrated less immunoreactivity of two oligodendrocyte-associated proteins in schizophrenia (2',3'-cyclic nucleotide 3'-phosphodiesterase by 33%, P = 0.05; myelin-associated glycoprotein by 27%, P = 0.14). Impaired myelination in schizophrenia could contribute to abnormalities of neural connectivity and persistent functional impairment in the illness.