Slow sites in an exclusion process with limited resources
Slow sites in an exclusion process with limited resources
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DOI：
10.1103/physreve.82.051920
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发表时间：
2010-11-17
影响因子：
2.4
通讯作者：
Thiel, Marco
中科院分区：
文献类型：
--
作者：
Brackley, Chris A.;Romano, M. Carmen;Thiel, Marco
我们引入缓慢的瓶颈站点到最近扩展的完全不对称的排斥过程中，允许跳频速率动态变化的资源的可用性。在生物学中信使RNA（mRNA）翻译的背景下，这是指氨基酸转移RNA（aa-tRNA）复合物的可用性，其作为蛋白质生产的氨基酸来源。我们研究了一个简单的设计师mRNA与一个单一的缺陷密码子在中心。除了熟悉的排队行为外，我们还观察到排队阶段内的一种状态，其中随着aa-tRNA耗尽，排队变得不那么严重。
We introduce slow bottleneck sites into a recent extension of the totally asymmetric exclusion process where hopping rates are allowed to vary dynamically with the availability of resources. In the context of messenger RNA (mRNA) translation in biology, this refers to the availability of amino acid-transfer-RNA (aa-tRNA) complexes which act as the source of amino acids for protein production. We study a simple designer mRNA with a single defect codon in the center. As well as the familiar queuing behavior we also observe a regime within the queuing phase where the queue becomes less severe as the aa-tRNAs become depleted.