Cellular Evidence of Telocytes as Novel Interstitial Cells Within the Magnum of Chicken Oviduct
Cellular Evidence of Telocytes as Novel Interstitial Cells Within the Magnum of Chicken Oviduct
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鸡输卵管输卵管内特洛细胞作为新型间质细胞的细胞证据
DOI：
10.3727/096368916x692942
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发表时间：
2017
影响因子：
3.3
通讯作者：
Chen Qiusheng
中科院分区：
文献类型：
--
作者：
Yang Ping;Zhu Xudong;Wang Lingling;Ahmed Nisar;Huang Yufei;Chen Hong;Zhang Qian;Ullah Shakeeb;Liu Tengfei;Guo Dawei;Brohi Sarfaraz Ahmed;Chen Qiusheng
远端细胞是一种新型的间质细胞，已在哺乳动物的许多器官中发现，但在鸟类中对这些细胞的研究很少。本研究用透射电镜分析了鸡输卵管大网膜肌层和固有层中远端细胞的最新发现。远端细胞的特征是端足，端足长而薄，细胞质少量，富含线粒体。在大网膜的不同部位可见梭形或三角形的远端细胞。在肌层，远端细胞与平滑肌细胞直接相连。远端细胞的细胞体及其长端足主要存在于平滑肌束之间的间隙中，而大量的短端足分散在平滑肌细胞之间。在固有层中，极长的端足相互缠绕，通常含有胶原蛋白。无论是在固有层还是在肌层，远端细胞都与其他细胞类型，如免疫细胞和血管有密切的关系。端足动物在足部和足部之间交替出现二叉分支，形成具有复杂的同质和异质细胞连接的三维网络结构。此外，端足周围可见独特大小的囊泡，由于囊泡与端足之间的密切关系，囊泡可能从端足释放出来。大网膜中远端细胞的所有特征表明，远端细胞可能在输卵管疾病的发病机制中发挥着潜在但重要的作用。
Telocytes are a novel type of interstitial cell that has been identified in many organs of mammals, but there is little information available on these cells in avian species. This study shows the latest findings associated with telocytes in the muscular layer and lamina propria of the magnum of chicken oviduct analyzed by transmission electron microscopy. Telocytes are characterized by telopodes, which are thin and long prolongations, and a small amount of cytoplasm rich with mitochondria. Spindle- or triangular-shaped telocytes were detected at various locations in the magnum. In the muscular layer, telocytes have direct connection with smooth muscle cells. The cell body of telocytes along with their long telopodes mainly exists in the interstitial space between the smooth muscle bundles, whereas large numbers of short telopodes are scattered in between the smooth muscle cells. In the lamina propria, extremely long telopodes are twisting around each other and are usually collagen embedded. Both in the lamina propria and muscular layer, telocytes have a close relationship with other cell types, such as immune cells and blood vessels. Telopodes appear with dichotomous branching alternating between the podom and podomer, forming a 3D network structure with complex homo- and heterocellular junctions. In addition, a distinctive size of the vesicles is visible around the telopodes and may be released from telopodes because of the close relation between the vesicle and telopode. All characteristics of telocytes in the magnum indicate that telocytes may play a potential, but important, role in the pathogenesis of oviduct diseases.