AUTOSOMAL RECESSIVE INHERITANCE OF AIRWAY HYPERREACTIVITY TO 5-HYDROXYTRYPTAMINE
AUTOSOMAL RECESSIVE INHERITANCE OF AIRWAY HYPERREACTIVITY TO 5-HYDROXYTRYPTAMINE
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DOI：
10.1152/jappl.1989.67.3.1125
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发表时间：
1989-09-01
影响因子：
3.3
通讯作者：
MITZNER, W
中科院分区：
文献类型：
--
作者：
LEVITT, RC;MITZNER, W
我们之前报道过，A/J和C3H/HeJ小鼠及其杂交后代的气道对乙酰胆碱（Ach）的高反应性是一种常染色体隐性遗传性状（FASEB J. 2: 2605-2608, 1988）。在本报告中，我们通过评估多个基因标准化的近交系小鼠对5-羟色胺（5-HT）和乙酰胆碱的气道反应的生物学变异性来扩展这些研究。9个近交系小鼠气道对乙酰胆碱的反应模式与5-羟色胺的反应模式有显著差异。A/J小鼠对5-HT和乙酰胆碱均表现出非特异性气道高反应性。DBA/2J小鼠对5-HT有高反应，但对乙酰胆碱无高反应。与这些自交系相似的气道表型称为高反应性。C3H/HeJ和c57BL/6J自交系对乙酰胆碱和5-羟色胺的反应最小。与这些最低反应性菌株相似的气道表型被称为低反应性菌株。A/J小鼠与C3H/HeJ小鼠或DBA/2J小鼠与C57BL/6J小鼠杂交产生高反应性和低反应性后代的频率与单个常染色体隐性基因一致，主要决定气道对5-HT的高反应性。我们报告的连锁研究表明，这些基因并不密切相关，5-HT和乙酰胆碱气道高反应性是独立遗传的。这些研究结果表明，小鼠非特异性气道高反应性是由多个基因决定的。
We have previously reported that airway hyperresponsiveness to acetylcholine (Ach) is inherited as an autosomal recessive trait in A/J and C3H/HeJ mice and the progeny of crosses between them (FASEB J. 2: 2605-2608, 1988). In the present report, we have extended these studies by evaluating the biological variability in the airway response to 5-hydroxytryptamine (5-HT) and ACh among multiple genetically standardized inbred strains of mice. The pattern of airway responsiveness to ACh differed significantly from that of 5-HT in nine inbred strains of mice. A/J mice showed nonspecific airway hyperresponsiveness to both 5-HT and ACh. DBA/2J mice were hyperresponsive to 5-HT but not to ACh. An airway phenotype that resembled these inbred strains is termed HYPERREACTIVE. The C3H/HeJ and c57BL/6J inbred strains wwere minimally reactive to either ACh or 5-HT. Airway phenotypes that resembled these minimally reactive strains are termed HYPOREACTIVE. The frequency of HYPERREACTIVE and HYPOREACTIVE offspring from crosses between A/J and C3H/HeJ mice or DBA/2J and C57BL/6J mice is consistent with a single autosomal recessive gene, primarily determining airway hyperresponsiveness to 5-HT. We report linkage studies which suggest that these genes are not closely linked and that 5-HT and ACh airway hyperresponsiveness is inherited independently. The results of these studies suggest that murine nonspecific airway hyperresponsiveness is determined by multiple genes.