Simian virus 40 sequences in malignant lymphomas in Japan.
Simian virus 40 sequences in malignant lymphomas in Japan.
复制标题
日本恶性淋巴瘤中的猿猴病毒 40 序列。
作者：
S. Nakatsuka;Angen Liu;Z. Dong;S. Nomura;T. Takakuwa;H. Miyazato;K. Aozasa
Recent studies showed that SV40 is detected in >40% of non-Hodgkin's lymphoma (NHL) in United States, suggesting SV40-contaminated poliovaccines widely used during the period 1955-1963 to be a major source of SV40 in NHL. We examined the presence of SV40 sequences in 122 cases with NHL and 3 with Hodgkin's lymphoma from Japan. The detection rate of SV40 sequences in diffuse large B-cell lymphoma (19%) was higher than that in peripheral blood cells of normal healthy volunteers in Japan (4.7%; P < 0.05) reported previously as controls for comparison with the study results from cancer patients, suggesting a role for SV40 in the development of diffuse large B-cell lymphoma. In contrast, the frequency of SV40 sequences in NHL cases born between 1951 and 1963 (12%), during which SV40-contaminated poliovaccines might have been inoculated, is not significantly different from that in cases born before 1950 (11%) or after 1964 (15%). SV40 is a new candidate etiologic factor for malignant lymphoma not only in the United States but also in Japan.
猿猴病毒 40 存在于大多数美国人类间皮瘤中，但很少存在于非霍奇金淋巴瘤中。
影响因子：
9.6
作者：
Rizzo,P;Carbone,M;Fisher,SG;Matker,C;Swinnen,LJ;Powers,A;DiResta,I;Alkan,S;Pass,HI;Fisher,RI
通讯作者：
Fisher,RI